Journal
NUCLEIC ACIDS RESEARCH
Volume 45, Issue D1, Pages D200-D203Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkw1129
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Funding
- Intramural Research Program of the National Library of Medicine at National Institutes of Health/DHHS
- Intramural Research Program of the National Library of Medicine, National Institutes of Health
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NCBI's Conserved Domain Database (CDD) aims at annotating biomolecular sequences with the location of evolutionarily conserved protein domain footprints, and functional sites inferred from such footprints. An archive of pre-computed domain annotation is maintained for proteins tracked by NCBI's Entrez database, and live search services are offered as well. CDD curation staff supplements a comprehensive collection of protein domain and protein family models, which have been imported from external providers, with representations of selected domain families that are curated in-house and organized into hierarchical classifications of functionally distinct families and sub-families. CDD also supports comparative analyses of protein families via conserved domain architectures, and a recent curation effort focuses on providing functional characterizations of distinct subfamily architectures using SPARCLE: Subfamily Protein Architecture Labeling Engine.
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