Journal
NUCLEIC ACIDS RESEARCH
Volume 44, Issue 11, Pages -Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkw208
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Funding
- Del E. Webb Foundation [13-2-28]
- Army Research Office [W911NF-14-1-0507]
- National Science Foundation [CCF-1317640]
- Direct For Computer & Info Scie & Enginr [1317640] Funding Source: National Science Foundation
- Division of Computing and Communication Foundations [1317640] Funding Source: National Science Foundation
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [1317694] Funding Source: National Science Foundation
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Scalable production of DNA nanostructures remains a substantial obstacle to realizing new applications of DNA nanotechnology. Typical DNA nanostructures comprise hundreds of DNA oligonucleotide strands, where each unique strand requires a separate synthesis step. New design methods that reduce the strand count for a given shape while maintaining overall size and complexity would be highly beneficial for efficiently producing DNA nanostructures. Here, we report a method for folding a custom template strand by binding individual staple sequences to multiple locations on the template. We built several nanostructures for well-controlled testing of various design rules, and demonstrate folding of a 6-kb template by as few as 10 unique strand sequences binding to 10 +/- 2 locations on the template strand.
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