Journal
NUCLEIC ACIDS RESEARCH
Volume 44, Issue W1, Pages W356-W360Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkw304
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Funding
- Consejo de Investigaciones Cientificas y Tecnicas (CONICET)
- Agencia Nacional de Promocion Cientifica y Tecnologica from the National Institute of General Medical Sciences [PICT2012/01647]
- Agencia Nacional de Promocion Cientifica y Tecnologica [PPG Grant] from the National Institute of General Medical Sciences [P01GM071862]
- D.R. Bullard-Welch Chair at Rice University [C-0016]
- Agencia Nacional de Promocion Cientifica y Tecnologica
- Direct For Mathematical & Physical Scien
- Division Of Physics [1427654] Funding Source: National Science Foundation
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The protein frustratometer is an energy landscape theory-inspired algorithm that aims at localizing and quantifying the energetic frustration present in protein molecules. Frustration is a useful concept for analyzing proteins' biological behavior. It compares the energy distributions of the native state with respect to structural decoys. The network of minimally frustrated interactions encompasses the folding core of the molecule. Sites of high local frustration often correlate with functional regions such as binding sites and regions involved in allosteric transitions. We present here an upgraded version of a webserver that measures local frustration. The new implementation that allows the inclusion of electrostatic energy terms, important to the interactions with nucleic acids, is significantly faster than the previous version enabling the analysis of large macromolecular complexes within a user-friendly interface. The webserver is freely available at URL: http://frustratometer.qb.fcen.uba.ar.
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