Journal
NUCLEIC ACIDS RESEARCH
Volume 44, Issue 4, Pages 1496-1501Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkw012
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Funding
- Australia Research Council (ARC) Future Fellowship Award from the ARC, Australia
- Australia Research Council [FT140100128]
- Australian Research Council [FT140100128] Funding Source: Australian Research Council
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A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.
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