Journal
NUCLEIC ACIDS RESEARCH
Volume 44, Issue 5, Pages 1989-2006Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkw079
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Funding
- Intramural Research program of the National Institutes of Health, NIA
- Agence Nationale de la Recherche (ANR) [ANR-12-IS07-0001, ANR-12-BSV8-0008-01, ANR-10-NANO-04-03]
- Inserm
- Conseil Regional d'Aquitaine
- Agence Nationale de la Recherche (ANR) [ANR-12-IS07-0001] Funding Source: Agence Nationale de la Recherche (ANR)
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Guanine-rich DNA strands can fold in vitro into non-canonical DNA structures called G-quadruplexes. These structures may be very stable under physiological conditions. Evidence suggests that G-quadruplex structures may act as 'knots' within genomic DNA, and it has been hypothesized that proteins may have evolved to remove these structures. The first indication of how G-quadruplex structures could be unfolded enzymatically came in the late 1990s with reports that some well-known duplex DNA helicases resolved these structures in vitro. Since then, the number of studies reporting G-quadruplex DNA unfolding by helicase enzymes has rapidly increased. The present review aims to present a general overview of the helicase/G-quadruplex field.
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