Journal
NUCLEIC ACIDS RESEARCH
Volume 44, Issue 7, Pages 2987-2999Publisher
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkw151
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Funding
- National Institutes of Health [GM086663, AT007886]
- Defense Advanced Research Agency [HR0011-11-2-0002]
- Human Frontiers Science Program [RGP0054/2013]
- Oxford University Press-NAR
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The past decade of synthetic biology research has witnessed numerous advances in the development of tools and frameworks for the design and characterization of biological systems. Researchers have focused on the use of RNA for gene expression control due to its versatility in sensing molecular ligands and the relative ease by which RNA can be modeled and designed compared to proteins. We review the recent progress in the field with respect to RNA-based genetic devices that are controlled through small molecule and protein interactions. We discuss new approaches for generating and characterizing these devices and their underlying components. We also highlight immediate challenges, future directions and recent applications of synthetic RNA devices in engineered biological systems.
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