Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 357, Issue 14-15, Pages 3141-3147Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500628
Keywords
cycloisomerization; flow chemistry; gold nanoparticles; green chemistry; heterogeneous catalysis
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Funding
- Agency for Innovation by Science and Technology (IWT)
- CatchBio
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A continuous-flow protocol for the gold-catalyzed cycloisomerization of sterically hindered Ugi-adducts to spiroindolines in a packed-bed reactor is presented. Spiroindolines with various substitution patterns are formed in good yields and with good selectivity. A detailed characterization of the catalyst deactivation process was conducted, whereas no metal leaching from the catalyst was detected.
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