Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 357, Issue 13, Pages 2944-2950Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500580
Keywords
alkynes; annulation; C-H activation; nitrones; oxidizing directing group; rhodium
Categories
Funding
- National Basic Research Program of China [2015CB856600]
- National Natural Science Foundation of China [21202184, 21232006]
- Chinese Academy of Sciences
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By using a nitrone as the oxidizing directing group, a mild, practical and efficient rhodium(III)-catalyzed C-H functionalization for the synthesis of indole derivatives has been developed. This reaction obviates the need for an external oxidant and shows good functional group tolerance. The employment of a sterically hindered Mes group on the carbon center of the nitrone is crucial to produce indoles in high yield.
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