Journal
CHEMISTRY AND PHYSICS OF LIPIDS
Volume 188, Issue -, Pages 61-67Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.chemphyslip.2015.05.002
Keywords
Phospholipid; n-Alkane; Phase transition; Lipid packing; Head group dependence
Categories
Funding
- JSPS [42740289]
- Grants-in-Aid for Scientific Research [15J04751] Funding Source: KAKEN
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Phase behavior and structural properties were examined for phospholipid bilayers having different headgroups (DMPC, DMPS and DMPE) with added n-alkanes to study effect of flexible additives. Change in the temperatures of main transition of the lipid/alkane mixtures against the length of added alkanes depends largely on the headgroup. Theoretical analysis of the change of the temperature of transition indicates that the headgroup dependence is dominantly originated in the strong dependence of total enthalpy on the headgroups. The results of X-ray diffraction show that the enthalpic stabilization due to enhanced packing of acyl chains of the lipid by alkanes in the gel phase causes the headgroup-dependent change in the phase transition behavior. The enhanced packing in the gel phase also leads to easy emergence of the subgel phase with very short relaxation time at room temperature in the DMPE-based bilayers. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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