Journal
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
Volume 55-56, Issue -, Pages 91-100Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.niox.2016.04.002
Keywords
Carbon monoxide; Evolution; Geoscience; Hydrogen sulfide; Nitric oxide; Reactive oxygen species
Categories
Funding
- JSPS KAKENHI from Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan [15H02843]
- Grants-in-Aid for Scientific Research [15H02843] Funding Source: KAKEN
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Hydrogen sulfide (H2S) is produced in the mammalian body through the enzymatic activities of cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CSE) and 3-mercaptopyruvate sulfurtransferase (3MST). A growing number of studies have revealed that biogenic H2S produced in tissues is involved in a variety of physiological responses in mammals including vasorelaxation and neurotransmission. It is now evident that mammals utilize H2S to regulate multiple signaling systems, echoing the research history of the gaseous signaling molecules nitric oxide (NO) and carbon monoxide (CO) that had previously only been recognized for their cytotoxicity. In the human diet, meats (mammals, birds and fishes) and vegetables (plants) containing cysteine and other sulfur compounds are the major dietary sources for endogenous production of H2S. Plants are primary producers in ecosystems on the earth and they synthesize organic sulfur compounds through the activity of sulfur assimilation. Although plant H2S-producing activities have been known for a long time, our knowledge of H2S biology in plant systems has not been updated to the extent of mammalian studies. Here we review recent progress on H2S studies, highlighting plants and bacteria. Scoping the future integration of H2S, NO and O-2 biology, we discuss a possible linkage between physiology, ecology and evolutional biology of gas metabolisms that may reflect the historical changes of the Earth's atmospheric composition. (C) 2016 Elsevier Inc. All rights reserved.
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