Journal
CHEMISTRY & BIODIVERSITY
Volume 12, Issue 4, Pages 593-598Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbdv.201400161
Keywords
Atractylodes lancea; Tribolium castaneum; Contact toxicity; Repellency; Atractylodin; Atractylenolides II and III
Funding
- National Natural Science Foundation of China [81202919]
- Special Scientific Research for Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine of China [20110700712]
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During a screening program for new agrochemicals from Chinese medicinal herbs and local wild plants, the petroleum ether (PE) extract of Atractylodes lancea (Thunb.) rhizomes was found to possess repellent and contact activities against Tribolium castaneum adults. Bioactivity-directed chromatographic separation of PE extract on repeated silica-gel columns led to the isolation of two polyacetylenes, atractylodin and atractylodinol (1 and 2, resp.), and two lactones, atractylenolides II and III (3 and 4, resp.). The structures of the compounds were elucidated based on NMR spectra. The four isolated compounds were evaluated for their insecticidal and repellent activities against T. castaneum. Atractylodin exhibited strong contact activity against T. castaneum adults with a LD50 value of 1.83g/adult. Atractylodin and atractylenolide II also possessed strong repellenct activities against T. castaneum adults. After 4-h exposure, >90% repellency was achieved with atractylodin at a low concentration of 0.63g/cm(2). The results indicated that atractylodin (1) and atractylenolide II (3) have a good potential as a source for natural repellents, and 1 has the potential to be developed as natural insecticide.
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