Respiratory syncytial virus epidemiology and clinical severity before and during the COVID-19 pandemic in British Columbia, Canada: a retrospective observational study

Letter Infectious Diseases

Decline of RSV-specific antibodies during the COVID-19 pandemic

Gerco den Hartog et al.

LANCET INFECTIOUS DISEASES (2023)

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Letter Pediatrics

Shifting Epidemiology and Severity of Respiratory Syncytial Virus in Children During the COVID-19 Pandemic

Suchitra Rao et al.

JAMA PEDIATRICS (2023)

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Review Medicine, General & Internal

Why has the epidemiology of RSV changed during the COVID-19 pandemic?

Bahaa Abu-Raya et al.

Summary: The COVID-19 pandemic has had a profound impact on the epidemiology of Respiratory Syncytial Virus (RSV) infections in children. Various theories have been proposed to explain this change, including decreased viral immunity, immune dysregulation induced by SARS-CoV-2, viral interactions between SARS-CoV-2 and RSV, and changes in health-seeking behaviors and healthcare systems. Further research in viral genomics and immunology is needed to guide RSV prevention and healthcare resource planning.

ECLINICALMEDICINE (2023)

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Letter Pediatrics

Examining the entire delayed respiratory syncytial virus season in Western Australia

David Anthony Foley et al.

ARCHIVES OF DISEASE IN CHILDHOOD (2022)

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Article Immunology

Implications of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Pandemic on the Epidemiology of Pediatric Respiratory Syncytial Virus Infection

Oludare A. Odumade et al.

Summary: Respiratory viral infections have a significant impact on global disease and mortality. The coronavirus disease 2019 pandemic has brought about drastic changes in the seasonality patterns and mitigation efforts of respiratory syncytial virus, highlighting the urgent need for vaccination as a preventive tool.

CLINICAL INFECTIOUS DISEASES (2022)

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Article Immunology

Waning Immunity Against Respiratory Syncytial Virus During the Coronavirus Disease 2019 Pandemic

Frederic Reicherz et al.

Summary: This article reports a reduction in RSV antibody levels and neutralization activity in serum from women of childbearing age and infants during the COVID-19 pandemic, supporting the notion of relatively short-lived antibody immunity in infants and explaining the interseasonal resurgence of RSV cases.

JOURNAL OF INFECTIOUS DISEASES (2022)

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Article Medicine, General & Internal

Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in children younger than 5 years in 2019: a systematic analysis

You Li et al.

Summary: Respiratory syncytial virus (RSV) plays a significant role in morbidity and mortality burden globally in children aged 0-60 months, especially during the first 6 months of life and in low-income and middle-income countries. Passive immunization programs targeting RSV could have a substantial effect on reducing disease burden.

LANCET (2022)

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Article Medicine, General & Internal

Serial cross-sectional estimation of vaccine-and infection-induced SARS-CoV-2 seroprevalence in British Columbia, Canada

Danuta M. M. Skowronski et al.

Summary: This study examined the seroprevalence of vaccine- and infection-induced antibodies to SARS-CoV-2 in British Columbia, Canada across the different stages of the COVID-19 pandemic. The results showed that by August 2022, most children and adults younger than 60 years had evidence of both vaccination and infection. The findings suggest the importance of continued prioritized vaccination for older adults.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2022)

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Article Immunology

Impact of Coronavirus Disease 2019 Public Health Measures on Detections of Influenza and Respiratory Syncytial Virus in Children During the 2020 Australian Winter

Daniel K. Yeoh et al.

Summary: Public health measures aimed at COVID-19 have led to significant reductions in respiratory syncytial virus and influenza detections among children in Western Australia during winter 2020, despite schools reopening. Border closures are likely playing a key role in limiting external introductions of respiratory viruses.

CLINICAL INFECTIOUS DISEASES (2021)

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Letter Immunology

Changing Epidemiology of Respiratory Syncytial Virus in Australia-Delayed Re-Emergence in Victoria Compared to Western Australia/New South Wales (WA/NSW) After Prolonged Lock-Down for Coronavirus Disease 2019 (COVID-19)

Sarah McNab et al.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Immunology

Changes in Seasonal Respiratory Illnesses in the United States During the Coronavirus Disease 2019 (COVID-19) Pandemic

Loren Rodgers et al.

Summary: During the COVID-19 pandemic, there were changes in the patterns of respiratory illnesses, with an initial increase in respiratory symptoms followed by a decrease in ED visits for most respiratory conditions. The positivity rates for respiratory viruses were lower in 2020 compared to 2019, except for rhinovirus/enterovirus which showed an increase in positivity towards the end of 2020.

CLINICAL INFECTIOUS DISEASES (2021)

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Article Multidisciplinary Sciences

Population-based serology reveals risk factors for RSV infection in children younger than 5 years

Stijn P. Andeweg et al.

Summary: RSV infection is a common occurrence in children, with the majority experiencing it before the age of 2. Age and birthdate are significant predictors of RSV infection probability, with children born in summer having a higher likelihood of infection.

SCIENTIFIC REPORTS (2021)

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Article Medicine, Research & Experimental

A majority of uninfected adults show preexisting antibody reactivity against SARS-CoV-2

Abdelilah Majdoubi et al.

Summary: Research suggests that most adults exhibit preexisting antibody cross-reactivity against SARS-CoV-2, involving spike protein among others. This finding supports further investigation into how this may impact the clinical severity of COVID-19 or SARS-CoV-2 vaccine responses.

JCI INSIGHT (2021)

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Editorial Material Medicine, General & Internal

Potential resurgence of respiratory syncytial virus in Canada

Pascal M. Lavoie et al.

CANADIAN MEDICAL ASSOCIATION JOURNAL (2021)

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Article Infectious Diseases

Impact of public health measures on the post-COVID-19 respiratory syncytial virus epidemics in France

Jacques Fourgeaud et al.

Summary: The study described the impact of public health measures on RSV severe infections in France during the COVID-19 pandemic. The 2020/2021 RSV outbreak in France involved more children aged 6 to 11 months, but less infants aged < 6 months and less adults compared to previous outbreaks. The outbreak in 2020/2021 resulted in shorter hospital stays, less frequent admission to intensive care unit, and less use of non-invasive ventilation or high-flow nasal oxygen therapy than previous outbreaks.

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES (2021)

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Editorial Material Pediatrics

Delayed Seasonal RSV Surge Observed During the COVID-19 Pandemic

Rabia Agha et al.

PEDIATRICS (2021)

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Article Medicine, General & Internal

Seasonality of Respiratory Viruses at Northern Latitudes

Michael T. Hawkes et al.

Summary: A study conducted in Alberta, Canada, showed that the seasonality of respiratory viruses followed a pattern estimated by simple mathematical models. This may be informative for anticipating future waves of pandemic SARS-CoV-2.

JAMA NETWORK OPEN (2021)

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Review Infectious Diseases

Pediatric Infectious Disease Group (GPIP) position paper on the immune debt of the COVID-19 pandemic in childhood, how can we fill the immunity gap?

Robert Cohen et al.

Summary: The COVID-19 pandemic has reduced the incidence of many viral and bacterial infections in children, leading to a positive short-term effect of preventing healthcare system overload. However, the reduced exposure to pathogens and vaccination rates may result in a potential immunity debt and increase the risk of future epidemics when non-pharmaceutical interventions are lifted.

INFECTIOUS DISEASES NOW (2021)

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Article Multidisciplinary Sciences