Valid lower bound for all estimators in quantum parameter estimation

The widely used quantum Cramer-Rao bound (QCRB) sets a lower bound for the mean square error of unbiased estimators in quantum parameter estimation, however, in general QCRB is only tight in the asymptotical limit. With a limited number of measurements biased estimators can have a far better performance for which QCRB cannot calibrate. Here we introduce a valid lower bound for all estimators, either biased or unbiased, which can serve as standard of merit for all quantum parameter estimations.