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Urinary biomarkers for amyotrophic lateral sclerosis: candidates, opportunities and considerations

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AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2019)

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Establishment of neurofilament light chain Simoa assay in cerebrospinal fluid and blood

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Combined use of CSF NfL and CSF TDP-43 improves diagnostic performance in ALS

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SCIENTIFIC REPORTS (2019)

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HMDB 4.0: the human metabolome database for 2018

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Panel of Oxidative Stress and Inflammatory Biomarkers in ALS: A Pilot Study

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Dramatic elevation in urinary amino terminal titin fragment excretion quantified by immunoassay in Duchenne muscular dystrophy patients and in dystrophin deficient rodents

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EMBO MOLECULAR MEDICINE (2017)

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Neurofilament Levels as Biomarkers in Asymptomatic and Symptomatic Familial Amyotrophic Lateral Sclerosis

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Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers

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AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2015)

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AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2014)

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Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

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Uridine ameliorates the pathological phenotype in transgenic G93A-ALS mice

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Proteome analysis reveals candidate markers of disease progression in amyotrophic lateral sclerosis (ALS)

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Cystatin C: A Candidate Biomarker for Amyotrophic Lateral Sclerosis

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Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis

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Cerebrospinal fluid tau protein is not a biological marker in amyotrophic lateral sclerosis

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Cystatin C in cerebrospinal fluid as a biomarker of ALS

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Sources of urinary proteins and their analysis by urinary proteomics for the detection of biomarkers of disease

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Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

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Oxidative stress biomarkers in sporadic ALS

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Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival

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Monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α as possible biomarkers for the chronic pelvic pain syndrome

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Bunina bodies in amyotrophic lateral sclerosis

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Cerebrospinal fluid neurofilament light levels in amyotrophic lateral sclerosis:: impact of SOD1 genotype

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CSF biomarkers for improved prognostic accuracy in acute CNS disease

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Ultrastructure of blood-brain barrier and blood-spinal cord barrier in SOD1 mice modeling ALS

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Conditional NF-L transgene expression in mice for in vivo analysis of turnover and transport rate of neurofilaments

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Astrocytes expressing ALS-linked mutated SOD1 release factors selectively toxic to motor neurons

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Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations

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Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

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Identification of potential CSF biomarkers in ALS

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Method for urinary neopterin measurements by HPLC

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Axonal damage markers in cerebrospinal fluid are increased in ALS

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Proteomic profiling of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis

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Exosomal-like vesicles are present in human blood plasma

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Neurofilament phosphoforms: Surrogate markers for axonal injury, degeneration and loss

A Petzold

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Urinary creatinine concentrations in the US population: Implications for urinary biologic monitoring measurements

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The ALSFRSr predicts survival time in an ALS clinic population

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Evidence for a critical role of the tumor necrosis factor α convertase (TACE) in ectodomain shedding of the p75 neurotrophin receptor (p75NTR)

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Identification and proteomic profiling of exosomes in human urine

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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

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Levels of urinary matrix metalloproteinase-9 (MMP-9) and renal injuries in patients with type 2 diabetic nephropathy

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Characterization of the low molecular weight human serum proteome

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MOLECULAR & CELLULAR PROTEOMICS (2003)

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Expression of the low affinity neurotrophin receptor p75 in spinal motoneurons in a transgenic mouse model for amyotrophic lateral sclerosis

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Proteomic analysis of normal human urinary proteins isolated by acetone precipitation or ultracentrifugation

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KIDNEY INTERNATIONAL (2002)

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Neopterin as a marker for immune system activation

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Neopterin measurement in clinical diagnosis

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Increased interleukin-6 of skin and serum in amyotrophic lateral sclerosis

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Urinary collagen metabolite excretion in amyotrophic lateral sclerosis

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MUSCLE & NERVE (2001)

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Increased oxidative damage to DNA in ALS patients

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FREE RADICAL BIOLOGY AND MEDICINE (2000)

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