Dietary polyphenols and their relationship to the modulation of non-communicable chronic diseases and epigenetic mechanisms: A mini-review

Chronic Non-Communicable Diseases (NCDs) have been considered a global health problem, characterized as diseases of multiple factors, which are developed throughout life, and regardless of genetics as a risk factor of important relevance, the increase in mortality attributed to the disease to environmental factors and the lifestyle one leads. Although the reactive species (ROS/RNS) are necessary for several physiological processes, their overproduction is directly related to the pathogenesis and aggravation of NCDs. In contrast, dietary polyphenols have been widely associated with minimizing oxidative stress and inflammation. In addition to their antioxidant power, polyphenols have also drawn attention for being able to modulate both gene expression and modify epigenetic alterations, suggesting an essential involvement in the prevention and/or development of some pa-thologies. Therefore, this review briefly explained the mechanisms in the development of some NCDs, followed by a summary of some evidence related to the interaction of polyphenols in oxidative stress, as well as the modulation of epigenetic mechanisms involved in the management of NCDs.

Automated summary

Chronic Non-Communicable Diseases (NCDs) are a global health problem characterized by multiple factors, lifelong development, and a significant increase in mortality due to environmental factors and lifestyle. The overproduction of reactive species (ROS/RNS) is directly associated with the pathogenesis and worsening of NCDs. Dietary polyphenols are widely recognized for their ability to reduce oxidative stress and inflammation. They have also been found to modulate gene expression and epigenetic alterations, suggesting a crucial role in the prevention and development of NCDs.