Ce6 nanoassemblies: Molecular mechanism and strategies for combinational anticancer therapy

Article Engineering, Environmental

Nanoformulations mediated metastasis brake in cancer therapy via photodynamic-enhanced ferroptosis and regional inflammation management

Jianwen Huang et al.

Summary: This study constructs a combinational drug delivery system to enhance tumor killing activity and inhibit metastasis through rational synergy of antitumor and anti-inflammatory functions.

CHEMICAL ENGINEERING JOURNAL (2023)

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Article Chemistry, Multidisciplinary

Cascade Immune Activation of Self-Delivery Biomedicine for Photodynamic Immunotherapy Against Metastatic Tumor

Rong-Rong Zheng et al.

Summary: Photodynamic therapy (PDT) is a promising antitumor modality that can generate reactive oxygen species (ROS) to induce cell apoptosis and immunogenic cell death (ICD). However, overexpressions of IDO and PD-L1 on tumor cells can inhibit immune activation. In this study, a self-delivery biomedicine was developed to enhance photodynamic immunotherapy by inhibiting IDO and blocking PD1/PDL1.

SMALL (2023)

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Article Pharmacology & Pharmacy

Photosensitive pro-drug nanoassemblies harboring a chemotherapeutic dormancy function potentiates cancer immunotherapy

Jianjun Cheng et al.

Summary: Immunotherapy combined with chemotherapy and photodynamic therapy has been successfully used to enhance anti-tumor immune responses. However, the development of multifunctional and biodegradable nano-immunostimulants remains a challenge. In this study, a carrier-free nano-prodrug COS-BA/Ce6 NPs was designed, which showed improved antitumor efficacy by combining three multifunctional components. The nano-drugs exhibited low cytotoxicity, pH-responsiveness, good biodegradability, and biocompatibility, making them highly efficient for synergistic photochemotherapy. When combined with anti-PD-L1 therapy, they effectively activated antitumor immunity, showing potential for clinical immunotherapy.

ACTA PHARMACEUTICA SINICA B (2023)

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Article Chemistry, Multidisciplinary

Targeting glutamine metabolism with photodynamic immunotherapy for metastatic tumor eradication

Linping Zhao et al.

Summary: In this study, a photodynamic immunostimulant called BVC was developed to enhance antitumor immunity by reprogramming glutamine metabolism, aiming to prevent immune escape and improve the clinical efficacy of immune checkpoint blockade (ICB) therapy.

JOURNAL OF CONTROLLED RELEASE (2023)

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Article Chemistry, Multidisciplinary

CDK4/6 nano-PROTAC enhances mitochondria-dependent photodynamic therapy and anti-tumor immunity

Tianyi Wang et al.

Summary: Cell cycle progression is highly activated in cancer cells, and CDK4/6 inhibition-based cell cycle arrest is a potent cancer treatment strategy. Combining CDK4/6 PROTAC with Chlorin e6-based photodynamic therapy has a synergistic anti-cancer effect, mediated by mitochondria accumulation and activation, resulting in increased production of reactive oxygen species and apoptosis.

NANO TODAY (2023)

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Article Nanoscience & Nanotechnology

Non-invasive activation of intratumoural gene editing for improved adoptive T-cell therapy in solid tumours

Xiaohong Chen et al.

Summary: The authors develop a temperature-sensitive system for delivering a Cas9 gene-editing sequence to target resistance mechanisms in cancer cells, which enhances T-cell delivery and improves therapeutic outcomes.

NATURE NANOTECHNOLOGY (2023)

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Article Engineering, Biomedical

Self-Assembled Carrier-Free Nanodrugs for Starvation Therapy-Amplified Photodynamic Therapy of Cancer

Dong-Yang Zhang et al.

Summary: In this study, carrier-free self-assembled nanoparticles, GC NPs, were developed by integrating glucose transporter 1 inhibitor genistein (Gen) and photosensitizer chlorin e6 (Ce6). GC NPs effectively cut off tumor glucose uptake and reduce tumor oxygen consumption, enhancing the therapeutic effect of photodynamic therapy (PDT). In vitro and in vivo experiments demonstrated the excellent synergistic antitumor efficacy of GC NPs without apparent toxicity. Moreover, fluorescence and photoacoustic imaging showed the excellent tumor enrichment efficiency of GC NPs, providing guidance for in vivo PDT. This carrier-free self-assembled GC NPs strategy holds promising clinical prospects for starvation therapy-amplified PDT.

ADVANCED HEALTHCARE MATERIALS (2023)

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Article Chemistry, Multidisciplinary

Carrier-Free Immunotherapeutic Nano- Booster with Dual Synergistic Effects Based on Glutaminase Inhibition Combined with Photodynamic Therapy

Ziyi Mai et al.

Summary: The carrier-free immunotherapeutic nanobooster C9SN, constructed by the self-assembly of glutaminase inhibitor compound 968 (C968) and photosensitizer Chlorin e6, enhances the immunotherapeutic effect of photo-dynamic therapy (PDT) by preventing glutamine metabolism and amplifying intracellular oxidative stress. It also remodels the tumor microenvironment and activates cytotoxic T lymphocytes to suppress tumor growth.

ACS NANO (2023)

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Article Engineering, Biomedical

Self-delivery biomedicine for enhanced photodynamic therapy by feedback promotion of tumor autophagy

Shao-Yi Chen et al.

Summary: In this study, a self-delivery autophagy regulator named CeCe was developed for sensitized photodynamic therapy (PDT) by promoting autophagy. CeCe was prepared by assembling chlorin e6 (Ce6) with celastrol, which produced reactive oxygen species (ROS) and induced cell autophagy under light irradiation. CeCe demonstrated enhanced phototoxicity and superior therapeutic efficiency compared to monotherapy and combined treatment, suggesting a synergistic antitumor effect of PDT and autophagy promotion. This self-delivery nanomedicine may advance the development of co-delivery nanoplatforms for improved PDT efficacy.

ACTA BIOMATERIALIA (2023)

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Article Biotechnology & Applied Microbiology

A co-delivery system based on chlorin e6-loaded ROS-sensitive polymeric prodrug with self-amplified drug release to enhance the efficacy of combination therapy for breast tumor cells

Cui Wang et al.

Summary: Recently, combination therapies for tumors have gained popularity due to their synergistic effects in improving therapeutic efficacy and reducing side effects. This study developed a reactive oxygen species (ROS)-sensitive co-delivery micelle for synergistic chemo-photodynamic therapy. The micelle could generate sufficient ROS upon light irradiation, leading to photodynamic therapy and localized drug release.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2023)

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Article Engineering, Biomedical

Epigenetic reprogramming of carrier free photodynamic modulator to activate tumor immunotherapy by EZH2 inhibition

Linping Zhao et al.

Summary: In this study, a carrier free photodynamic modulator (CeTaz) was developed to improve the immunosuppressive tumor microenvironment and promote T cell recognition of tumors by epigenetic reprogramming. CeTaz, assembled by chlorine e6 (Ce6) and tazemetostat (Taz), exhibited robust photodynamic therapy (PDT) and induced immunogenic cell death (ICD) to activate effector T cells. Furthermore, CeTaz suppressed the methylation of H3K27 and promoted the expression of MHC-I and CXCL10 in tumor cells, enhancing antitumor immunity. The PDT activated immunotherapy of CeTaz inhibited both primary and distant tumor growth with low system toxicity, contributing to the development of carrier free nanomedicine for precise treatment of metastatic tumors.

BIOMATERIALS (2023)

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Article Engineering, Biomedical

A photodynamic-mediated glutamine metabolic intervention nanodrug for triple negative breast cancer therapy

Cancan Yu et al.

Summary: Glutamine addiction is a unique characteristic of triple negative breast cancer (TNBC), which can be targeted for intervention. Unfortunately, the effects of GLS inhibitors are hindered by glutamine resistance and their own instability and insolubility. Therefore, there is a need for a nanoplatform that can effectively harmonize glutamine metabolic intervention for TNBC therapy.

MATERIALS TODAY BIO (2023)

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Article Pharmacology & Pharmacy

Self-Delivery O2-Ecomonizer to Reverse Antiapoptosis of Hypoxic Tumor for Enhanced Photodynamic Therapy

Yan-Mei Li et al.

Summary: In this study, a self-delivery O-2-ecomonizer (CeTam) was developed to relieve hypoxia and reverse antiapoptotic pathway for enhanced photodynamic tumor therapy. This multifunctional nanoplatform can regulate unfavorable tumor microenvironments and improve the efficacy of photodynamic therapy on tumor elimination.

ADVANCED THERAPEUTICS (2023)

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Article Engineering, Biomedical

A supramolecular assembly strategy for hydrophilic drug delivery towards synergistic cancer treatment

Haijing Qu et al.

Summary: We propose a supramolecular assembly strategy to enhance drug loading, tumor targeting, and delivery simplicity for hydrophilic drugs. By co-assembling with other drugs, we validate the effectiveness of this strategy and demonstrate its application in anti-tumor activities.

ACTA BIOMATERIALIA (2023)

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Article Chemistry, Applied

Diselenide-triggered hydroxyethyl starch conjugate nanoparticles with cascade drug release properties for potentiating chemo-photodynamic therapy

Ronghua Tan et al.

Summary: A novel HES-SeSe-DOX conjugate was synthesized and self-assembled into HES-SeSe-DOX/Ce6 nanoparticles for chemo-photodynamic anti-tumor therapy. These nanoparticles disintegrated through cleavage or oxidation of diselenide-bridged linkages, resulting in cascade drug release. In vitro and in vivo studies demonstrated the enhanced cytotoxicity against tumor cells and tumor growth inhibition with good safety, suggesting the potential clinical use of HES-SeSe-DOX/Ce6 nanoparticles in chemo-photodynamic tumor therapy.

CARBOHYDRATE POLYMERS (2023)

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Article Chemistry, Multidisciplinary

Carrier-free nanodrugs for stemness inhibition-enhanced photodynamic therapy

Yuwei Liu et al.

Summary: The study prepared a carrier-free nanodrug MKCe6 NPs for effective tumor growth repression, which sensitized CSCs to PDT and demonstrated good performance in vitro and in vivo.

AGGREGATE (2023)

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Article Biochemistry & Molecular Biology

CDK4/6 inhibitors induce replication stress to cause long-term cell cycle withdrawal

Lisa Crozier et al.

Summary: CDK4/6 inhibitors can induce a prolonged G1 arrest, downregulate replisome components, impair origin licencing, and lead to long-lasting effects on tumor growth. This unexpected ability to induce DNA damage provides a rationale for predicting responsive tumor types and effective combination therapies.

EMBO JOURNAL (2022)

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Article Engineering, Biomedical

Self-Delivery Nanomedicine for Glutamine-Starvation Enhanced Photodynamic Tumor Therapy

Lin-Ping Zhao et al.

Summary: This study proposes inhibiting glutamine metabolism to enhance oxidative damage of photodynamic therapy (PDT) to tumor cells and develops a drug co-delivery system named CeV based on Ce6 and V9302. CeV shows improved cellular uptake and generates abundant reactive oxygen species under light irradiation. CeV inhibits glutamine uptake and amplifies oxidative stress, resulting in robust PDT efficacy on tumor inhibition.

ADVANCED HEALTHCARE MATERIALS (2022)

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Review Biochemistry & Molecular Biology

Recent Developments in PROTAC-Mediated Protein Degradation: From Bench to Clinic

Zhenyi Hu et al.

Summary: PROTACs are an emerging technology that utilizes the ubiquitin-proteasome system for targeted protein degradation, showing great therapeutic potential in treating diseases. Over the past two decades, significant advancements have been made in PROTAC technology, with an increasing repertoire of targets.

CHEMBIOCHEM (2022)

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Review Pharmacology & Pharmacy

Tumor-activated carrier-free prodrug nanoparticles for targeted cancer Immunotherapy: Preclinical evidence for safe and effective drug delivery

Man Kyu Shim et al.

Summary: This review outlines the trends and advances in tumor immunotherapy using carrier-free prodrug nanoparticles (PDNPs). PDNPs have shown great potential in reversing immunosuppressive tumor microenvironment and enhancing the response to immune checkpoint blockade therapy. This strategy provides a safe and effective drug delivery method with improved therapeutic outcomes.

ADVANCED DRUG DELIVERY REVIEWS (2022)

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Article Chemistry, Physical

Self-delivery nanomedicine for vascular disruption-supplemented chemo-photodynamic tumor therapy

Yibin Liu et al.

Summary: A self-delivery nanomedicine based on a vascular disruptor and photosensitizer has been developed for synergistic tumor therapy. This nanomedicine can inhibit tumor growth through chemotherapy and photodynamic therapy, with low side effects in vivo.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Chemistry, Physical

A carrier-free supramolecular nanoprodrug based on lactose-functionalized dimeric camptothecin via self-assembly in water for targeted and fluorescence imaging-guided chemo-photodynamic therapy

Ke Ma et al.

Summary: A carrier-free supramolecular nanoprodrug was developed using lactose-functionalized dimeric camptothecin, showing high drug-loading capacity and active specific targetability, with the fluorescence signal of Ce6 enabling precise tracking and localization, while ROS cleavage of ATA linker triggered on-demand CPT release and exhibited killing effect on tumor cells for synergistic therapy combining chemotherapy and photodynamic therapy.

JOURNAL OF COLLOID AND INTERFACE SCIENCE (2022)

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Article Chemistry, Multidisciplinary

Size Optimization of Organic Nanoparticles with Aggregation-Induced Emission Characteristics for Improved ROS Generation and Photodynamic Cancer Cell Ablation

Shengming Gan et al.

Summary: This study presents a universal method to fabricate organic nanoparticles with controllable sizes and finds that approximately 45 nm is the optimal size for AIE nanoparticles in photodynamic therapy (PDT). Unlike conventional nanoparticles, AIE nanoparticles show enhanced fluorescence and ROS generation as their sizes increase from 6 to approximately 45 nm. Further increase in size enhances brightness but reduces ROS production. Experimental results confirm that 45 nm AIE nanoparticles exhibit the highest cellular uptake, deepest penetration depth, and best photodynamic killing effect.

SMALL (2022)

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Article Materials Science, Biomaterials

A self-delivery photodynamic sensitizer for enhanced DNA damage by PARP inhibition

Ren-Jiang Kong et al.

Summary: A self-delivery photodynamic sensitizer, CeOla, has been developed to enhance oxidative damage and sensitize tumor cells to photodynamic therapy (PDT) by blocking the DNA repair pathway. CeOla, which has a high drug content and favorable water stability, inhibits the activation of PARP, promotes the upregulation of gamma-H2AX, and reduces the expression of Rad51. The self-delivery CeOla greatly promotes tumor cell apoptosis and shows high antitumor performance with low side effects, making it a promising platform for the development of self-delivery nanomedicine to overcome oxidative resistance in tumor treatment.

BIOMATERIALS SCIENCE (2022)

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Article Chemistry, Applied

Self-assembly supramolecular drug delivery system for combination of photodynamic therapy and chemotherapy

Li Zhang et al.

Summary: A self-assembly supramolecular drug delivery system was successfully constructed to co-deliver Ce6 and YSL, demonstrating smart responsive properties in acidic tumor microenvironment and excellent antitumor effects in vivo, making it a promising approach for combination photodynamic therapy and chemotherapy.

JOURNAL OF MICROENCAPSULATION (2021)

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Article Nanoscience & Nanotechnology

Carrier-Free Triterpene Prodrugs with Glutathione Response and Biosafety for Synergistically Enhanced Photochemotherapy

Jianjun Cheng et al.

Summary: This study demonstrated the excellent antitumor therapeutic effects of carrier-free photosensitive prodrugs BA-S-S/Ce6 NPs, showcasing their synergistic enhancement in cancer therapy. Molecular dynamics simulations and density functional theory calculations elucidated the assembly mechanism and improved singlet oxygen generation mechanism of the nanoparticles.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Engineering, Environmental

Precisely engineering a carrier-free hybrid nanoassembly for multimodal DNA damage-augmented photodynamic therapy

Shumeng Li et al.

Summary: This study presents a facile and practical dual-drug co-assembly engineering strategy, constructs an efficient and versatile co-delivery nanoplatform, and demonstrates significant combination anticancer efficacy in vitro and in vivo. The dual-drug hybrid nanoassembly shows potential as a promising nanomedicine for clinical multimodal cancer therapy.

CHEMICAL ENGINEERING JOURNAL (2021)

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Article Nanoscience & Nanotechnology

A nanotherapeutic strategy to overcome chemotherapeutic resistance of cancer stem-like cells

Shiyang Shen et al.

Summary: This study presents a nanoparticle-based strategy for killing CSCs in tumors by inducing CSC differentiation with all-trans retinoic acid release under hypoxic conditions and triggering cell death with camptothecin release in response to increasing reactive oxygen species levels in differentiating CSCs.

NATURE NANOTECHNOLOGY (2021)

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Article Chemistry, Multidisciplinary

Solutions to the Drawbacks of Photothermal and Photodynamic Cancer Therapy

Xiangyu Deng et al.

Summary: Phototherapy, such as photothermal therapy and photodynamic therapy, has shown great potential in cancer treatment, but there are still many challenges that need to be addressed. Scientists are designing different systems to overcome the drawbacks associated with phototherapy, aiming to make it a more effective cancer treatment approach in clinical practice. This article discusses the problems and solutions in phototherapy research, providing insights for future advancements in the field.

ADVANCED SCIENCE (2021)

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Article Nanoscience & Nanotechnology

Low-Power Near-Infrared-Responsive Upconversion Nanovectors

Jun Xiang et al.

Summary: This study demonstrates a facile and effective strategy to construct surface-decorated UCPNVs based on Passerini three-component reaction, with tailored deprotecting wavelength that overlaps upconversion blue light. The resulting UCPNV exhibits efficient release of caged chlorambucil under very low 976 nm power, expanding the synthetic toolbox for quick development of UCPNVs for UCNP-assisted low-power NIR photochemistry.

ACS APPLIED MATERIALS & INTERFACES (2021)

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Article Materials Science, Biomaterials

Mn(II)-directed dual-photosensitizers co-assemblies for multimodal imaging-guided self-enhanced phototherapy

Jinxue Liu et al.

Summary: The study prepared a dual-photosensitizers co-assembly with high photosensitizer payload, excellent physiological stability, and outstanding tumor accumulation, which can be used for imaging-guided self-enhanced photodynamic therapy/photothermal therapy. The nanodrug not only improves the phototherapy efficiency but also has the potential for multi-modal imaging guided phototherapy.

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS (2021)

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Article Plant Sciences

A nanosensitizer self-assembled from oleanolic acid and chlorin e6 for synergistic chemo/sono-photodynamic cancer therapy

Yilin Zheng et al.

Summary: Self-assembled carrier-free nanosensitizer OC showed excellent anti-cancer activities in cancer cells, with strong tumor penetration ability and remarkable synergistic effects in combined chemotherapy and SPDT treatment.

PHYTOMEDICINE (2021)

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Review Pharmacology & Pharmacy

Liposome composition in drug delivery design, synthesis, characterization, and clinical application

Danielle E. Large et al.

Summary: Liposomal drug delivery is a highly adaptable therapeutic platform for treating a wide range of diseases. The molecular diversity in liposome composition enables drug delivery with unique physiological functions, such as pH response and reduced systemic toxicity.

ADVANCED DRUG DELIVERY REVIEWS (2021)

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Review Chemistry, Multidisciplinary

Small-Molecule Prodrug Nanoassemblies: An Emerging Nanoplatform for Anticancer Drug Delivery

Guanting Li et al.

Summary: SMP-NAs, formed by the self-assembly of prodrugs, have been widely investigated for their ultrahigh drug-loading and minimal adverse reactions, offering potential for improved antitumor efficiency compared to traditional nanomedicines. They are being used in chemotherapy, phototherapy, immunotherapy, and tumor diagnosis, and their co-delivery capabilities can address the challenges of tumor heterogeneity and multidrug resistance. Smart stimuli-responsive SMP-NAs and combination therapies based on SMP-NAs are also highlighted, emphasizing the structure-function relationships.

SMALL (2021)

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Article Chemistry, Multidisciplinary

Carrier Free Photodynamic Synergists for Oxidative Damage Amplified Tumor Therapy

Xin-Yu Li et al.

Summary: Self-delivery photodynamic synergists (PhotoSyn) enhance tumor therapy by increasing oxidative damage, with high drug loading rate and stability, and effective accumulation at tumor sites.

SMALL (2021)

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Article Engineering, Biomedical

Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy

Xuanbo Zhang et al.

Summary: Phototherapy as a non-invasive cancer treatment option faces challenges such as unsatisfactory therapeutic efficacy and severe phototoxicity. A new nanoassembly of Forster Resonance Energy Transfer (FRET) photosensitizer pairs has been developed to improve treatment efficiency and safety. The FRET pair-based nanoassembly allows controlled release of photosensitizer for photodynamic therapy, enhancing treatment efficacy while minimizing phototoxicity.

BIOACTIVE MATERIALS (2021)

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Review Oncology

Anti-angiogenesis in cancer therapeutics: the magic bullet

Ayodipupo S. Oguntade et al.

Summary: The use of anti-angiogenic therapy in cancer treatment is limited by tumor resistance and cardiovascular toxicity. Overcoming tumor resistance through dual anti-angiogenic therapy, combination therapy with chemotherapy and immunotherapy, and emerging nanoparticle-based therapy shows promise in improving the effectiveness of anti-angiogenic agents in cancer therapeutics.

JOURNAL OF THE EGYPTIAN NATIONAL CANCER INSTITUTE (2021)

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Review Medicine, Research & Experimental

Recent progress in nanomedicine for enhanced cancer chemotherapy

Guoqing Wei et al.

Summary: Nanomedicine has shown significant progress in improving cancer chemotherapy, including drug enrichment and tissue penetration, subcellular organelle-targeted chemotherapy, and reversal of multidrug resistance. The advantages of combination therapy in cancer treatment are emphasized.

THERANOSTICS (2021)

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Article Materials Science, Biomaterials

Exploring the self-assembly mechanism and effective synergistic antitumor chemophototherapy of a biodegradable and glutathione responsive ursolic acid prodrug mediated photosensitive nanodrug

Jianjun Cheng et al.

Summary: The study developed a multifunctional small molecule UASS and constructed carrier-free GSH-sensitive photosensitive nanocomposite UASS-Ce6 NPs for safe and synergistically improved chemophototherapy. These nanocomposites showed improved water solubility, enhanced intercellular ROS generation, desirable GSH sensibility, excellent biocompatibility, enhanced tumor accumulation, and rapid biodegradation.

BIOMATERIALS SCIENCE (2021)

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Article Chemistry, Multidisciplinary

A two-pronged photodynamic nanodrug to prevent metastasis of basal-like breast cancer

Jing Zhang et al.

Summary: The study proposed a two-pronged concept combining photodynamic therapy and epithelial-mesenchymal transition blockade to combat basal-like breast cancer metastasis. Ce6/Epa nanoparticles effectively prevented BLBC metastasis in vivo, offering a promising dual strategy against BLBC metastasis.

CHEMICAL COMMUNICATIONS (2021)

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Review Oncology

An update in clinical utilization of photodynamic therapy for lung cancer

Kai Wang et al.

Summary: Lung cancer is a leading cause of cancer-related deaths worldwide, with photodynamic therapy (PDT) showing promise as an effective treatment option. Clinical studies have demonstrated that PDT can prolong survival in inoperable cases.

JOURNAL OF CANCER (2021)

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Review Engineering, Biomedical

Tumor microenvironment targeted nanotherapeutics for cancer therapy and diagnosis: A review

Shreya Thakkar et al.

ACTA BIOMATERIALIA (2020)

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Review Nanoscience & Nanotechnology

Nanocarriers in photodynamic therapy-in vitro and in vivo studies

Krzysztof Sztandera et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2020)

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Article Chemistry, Multidisciplinary

Modularly Designed Peptide Nanoprodrug Augments Antitumor Immunity of PD-L1 Checkpoint Blockade by Targeting Indoleamine 2,3-Dioxygenase

Xuexiang Han et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)

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Article Chemistry, Multidisciplinary

Self-Delivery Nanomedicine for O2-Economized Photodynamic Tumor Therapy

Lin-Ping Zhao et al.

NANO LETTERS (2020)

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Article Biophysics

Novel carrier-free nanoparticles composed of 7-ethyl-10-hydroxycamptothecin and chlorin e6: Self-assembly mechanism investigation and in vitro/in vivo evaluation

Yanna Zhao et al.

COLLOIDS AND SURFACES B-BIOINTERFACES (2020)

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Review Chemistry, Medicinal

Emerging carrier-free nanosystems based on molecular self-assembly of pure drugs for cancer therapy

Xuanbo Zhang et al.

MEDICINAL RESEARCH REVIEWS (2020)

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Review Pharmacology & Pharmacy

Exploiting the dynamics of the EPR effect and strategies to improve the therapeutic effects of nanomedicines by using EPR effect enhancers

Jun Fang et al.

ADVANCED DRUG DELIVERY REVIEWS (2020)

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Article Nanoscience & Nanotechnology

Bioactive Natural Small Molecule-Tuned Coassembly of Photosensitive Drugs for Highly Efficient Synergistic and Enhanced Type I Photochemotherapy

Jianjun Cheng et al.

ACS APPLIED MATERIALS & INTERFACES (2020)

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Review Chemistry, Multidisciplinary

Dimeric prodrug-based nanomedicines for cancer therapy

Shumeng Li et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Review Chemistry, Multidisciplinary

Photothermal therapy

Defu Zhi et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Chemistry, Multidisciplinary

Self-Delivery Photo-Immune Stimulators for Photodynamic Sensitized Tumor Immunotherapy

Lin-Ping Zhao et al.

ACS NANO (2020)

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Article Chemistry, Multidisciplinary

Photosensitizer-stabilized self-assembling nanoparticles potentiate chemo/photodynamic efficacy of patient-derived melanoma

Lingling Huang et al.

JOURNAL OF CONTROLLED RELEASE (2020)

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Article Biochemistry & Molecular Biology

Inhibition of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

Jun-Kyu Byun et al.

MOLECULAR CELL (2020)

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Review Materials Science, Biomaterials

Nanomedicine-based tumor photothermal therapy synergized immunotherapy

Tongyi Shang et al.

BIOMATERIALS SCIENCE (2020)

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Article Chemistry, Multidisciplinary

A self-assembled carrier-free nanosonosensitizer for photoacoustic imaging-guided synergistic chemo-sonodynamic cancer therapy

Caihong Dong et al.

NANOSCALE (2020)

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Review Biochemistry & Molecular Biology

Molecular principles of metastasis: a hallmark of cancer revisited

Jawad Fares et al.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2020)

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Review Gastroenterology & Hepatology

Role of photodynamic therapy in the treatment of esophageal cancer

Hao Wu et al.

DIGESTIVE ENDOSCOPY (2019)

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Article Nanoscience & Nanotechnology

Simple and Multifunctional Natural Self-Assembled Sterols with Anticancer Activity-Mediated Supramolecular Photosensitizers for Enhanced Antitumor Photodynamic Therapy

Jianjun Cheng et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Multidisciplinary Sciences

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

Wei Li et al.

NATURE COMMUNICATIONS (2019)

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Article Medicine, Research & Experimental

Antitumor activity of the PD-1/PD-L1 binding inhibitor BMS-202 in the humanized MHC-double knockout NOG mouse

Tadashi Ashizawa et al.

BIOMEDICAL RESEARCH-TOKYO (2019)

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Article Chemistry, Multidisciplinary

Microfluidic Sonication To Assemble Exosome Membrane-Coated Nanoparticles for Immune Evasion-Mediated Targeting

Chao Liu et al.

NANO LETTERS (2019)

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Article Chemistry, Multidisciplinary

Immune Checkpoint Blockade Mediated by a Small-Molecule Nanoinhibitor Targeting the PD-1/PD-L1 Pathway Synergizes with Photodynamic Therapy to Elicit Antitumor Immunity and Antimetastatic Effects on Breast Cancer

Rui Zhang et al.

SMALL (2019)

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Article Nanoscience & Nanotechnology

Oxygen-Self-Supplying and HIF-1α-Inhibiting Core-Shell Nanosystem for Hypoxia-Resistant Photodynamic Therapy

Peng Liu et al.

ACS APPLIED MATERIALS & INTERFACES (2019)

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Article Biochemistry & Molecular Biology

A novel pro-apoptotic role of zinc octacarboxyphthalocyanine in melanoma me45 cancer cell's photodynamic therapy (PDT)

Joanna Nackiewicz et al.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY (2019)

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Article Chemistry, Multidisciplinary

Carrier-free nano-integrated strategy for synergetic cancer anti-angiogenic therapy and phototherapy

Zheng Wei et al.

CHEMICAL SCIENCE (2019)

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Review Pharmacology & Pharmacy

Production of pure drug nanocrystals and nano co-crystals by confinement methods

Flavia Fontana et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

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Review Pathology

The breast tumor microenvironment: role in cancer development, progression and response to therapy

Suruchi Mittal et al.

EXPERT REVIEW OF MOLECULAR DIAGNOSTICS (2018)

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Review Chemistry, Multidisciplinary

Modulating Hypoxia via Nanomaterials Chemistry for Efficient Treatment of Solid Tumors

Yanyan Liu et al.

ACCOUNTS OF CHEMICAL RESEARCH (2018)

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Article Materials Science, Biomaterials

An injectable dipeptide-fullerene supramolecular hydrogel for photodynamic antibacterial therapy

Yuankai Zhang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2018)

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Review Biochemistry & Molecular Biology

Effects of tumor metabolic microenvironment on regulatory T cells

Yi-an Wang et al.

MOLECULAR CANCER (2018)

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Review Pharmacology & Pharmacy

Tumor Microenvironment Targeted Nanotherapy

Clara Fernandes et al.

FRONTIERS IN PHARMACOLOGY (2018)

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Review Oncology

Cancer metabolism: a therapeutic perspective

Ubaldo E. Martinez-Outschoorn et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2017)

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Review Pharmacology & Pharmacy

Nanoprecipitation process: From encapsulation to drug delivery

Claudia Janeth Martinez Rivas et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

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Article Materials Science, Biomaterials

Chlorin e6 loaded lactoferrin nanoparticles for enhanced photodynamic therapy

Mahesh G. Adimoolam et al.

JOURNAL OF MATERIALS CHEMISTRY B (2017)

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Review Oncology

Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions

Demian van Straten et al.

CANCERS (2017)

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Review Oncology

Transport of drugs from blood vessels to tumour tissue

Mark W. Dewhirst et al.

NATURE REVIEWS CANCER (2017)

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Article Chemistry, Multidisciplinary

Inhibiting Metastasis and Preventing Tumor Relapse by Triggering Host Immunity with Tumor-Targeted Photodynamic Therapy Using Photosensitizer-Loaded Functional Nanographenes

Xinhe Yu et al.

ACS NANO (2017)

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Article Chemistry, Multidisciplinary

Peptide-Modulated Self-Assembly of Chromophores toward Biomimetic Light-Harvesting Nanoarchitectonics

Qianli Zou et al.

ADVANCED MATERIALS (2016)

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Review Biotechnology & Applied Microbiology

Molecular mechanisms of drug resistance and its reversal in cancer

Melis Kartal-Yandim et al.

CRITICAL REVIEWS IN BIOTECHNOLOGY (2016)

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Article Nanoscience & Nanotechnology

Carrier-Free, Chemophotodynamic Dual Nanodrugs via Self-Assembly for Synergistic Antitumor Therapy

Ruiyun Zhang et al.

ACS APPLIED MATERIALS & INTERFACES (2016)

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Article Chemistry, Multidisciplinary

A Photosensitizer-Loaded DNA Origami Nanosystem for Photodynamic Therapy

Xiaoxi Zhuang et al.

ACS NANO (2016)

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Article Chemistry, Multidisciplinary

Simple Peptide-Tuned Self-Assembly of Photosensitizers towards Anticancer Photodynamic Therapy

Kai Liu et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)

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Article Engineering, Biomedical

Activatable albumin-photosensitizer nanoassemblies for triple-modal imaging and thermal-modulated photodynamic therapy of cancer

Dehong Hu et al.

BIOMATERIALS (2016)

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