Journal
NEUROTHERAPEUTICS
Volume 13, Issue 4, Pages 762-774Publisher
SPRINGER
DOI: 10.1007/s13311-016-0475-x
Keywords
Gut microbiota; stroke; brain-gut microbiota axis; central nervous system; therapeutic target
Funding
- German Research Foundation [Exc 257]
- Federal Ministry of Education and Research [01 EO 08 01]
- International Max Planck Research School for Infectious Diseases and Immunology (IMPRS-IDI)
- Sonnenfeld-Stiftung
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Research on commensal microbiota and its contribution to health and disease is a new and very dynamically developing field of biology and medicine. Recent experimental and clinical investigations underscore the importance of gut microbiota in the pathogenesis and course of stroke. Importantly, microbiota may influence the outcome of cerebral ischemia by modulating central nervous system antigen-specific immune responses. In this review we summarize studies linking gut microbiota with physiological function and disorders of the central nervous system. Based on these insights we speculate about targeting the gut microbiome in order to treat stroke.
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