Related references
Note: Only part of the references are listed.A Brief Introduction to Chemical Reaction Optimization
Connor J. Taylor et al.
CHEMICAL REVIEWS (2023)
Drawing a Line: Where Might the Cohort of Concern End?
David J. Ponting et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2023)
Taking the Green Road Towards Pharmaceutical Manufacturing
Hans-Jurgen Federsel
SYNTHESIS-STUTTGART (2022)
Scaling up a C-H Borylation: Addressing the Safety Concerns of an Iridium-Catalyzed Process for Multikilo Scale Manufacture
Amanda Jane Lyons et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2022)
Batch or flow chemistry?-a current industrial opinion on process selection
Christian Holtze et al.
CURRENT OPINION IN CHEMICAL ENGINEERING (2022)
Fixed Bed Continuous Hydrogenations in Trickle Flow Mode: A Pharmaceutical Industry Perspective
Edward Masson et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2022)
Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution
Javier Magano
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2022)
Development of an Efficient Process to Prepare Methyl 4,5,6-Trichloropicolinate Using Highly Selective C-H Borylation/ Reactions
Xiaoyong Li et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2022)
Development of an Efficient New Route to PPARδ Agonist Fonadelpar: Formation of the C-C Bond by Claisen Condensation
Min Huang et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2022)
GREENER Pharmaceuticals for More Sustainable Healthcare
Caroline T. A. Moermond et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS (2022)
C-H Activation: Toward Sustainability and Applications
Toryn Dalton et al.
ACS CENTRAL SCIENCE (2021)
A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries
Guido Gambacorta et al.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY (2021)
Recent Trends in Enzyme Immobilization-Concepts for Expanding the Biocatalysis Toolbox
Hans-Jurgen Federsel et al.
MOLECULES (2021)
Air-stable 18-electron adducts of Schrock catalysts with tuned stability constants for spontaneous release of the active species
Henrik Gulyas et al.
COMMUNICATIONS CHEMISTRY (2021)
The application of modern reactions in large-scale synthesis
Kaitlyn Lovato et al.
NATURE REVIEWS CHEMISTRY (2021)
Evaluating and clustering retrosynthesis pathways with learned strategy
Yiming Mo et al.
CHEMICAL SCIENCE (2021)
Selected methods for the synthesis of sulfoxides and sulfones with emphasis on oxidative protocols
Sina Matavos-Aramyan et al.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS (2020)
The Grignard Reaction - Unraveling a Chemical Puzzle
Raphael Mathias Peltzer et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2020)
Toward a Scalable Synthesis and Process for EMA401, Part II: Development and Scale-Up of a Pyridine- and Piperidine-Free Knoevenagel-Doebner Condensation
Eric Sidler et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2020)
The 25th Anniversary of the Buchwald-Hartwig Amination: Development, Applications, and Outlook
Paola A. Forero-Cortes et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2019)
Explosion Hazards of Sodium Hydride in Dimethyl Sulfoxide, N,N-Dimethylformamide, and N,N-Dimethylacetamide
Qiang Yang et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2019)
Patent Review of Synthetic Routes and Crystalline Forms of the CFTR-Modulator Drugs Ivacaftor, Lumacaftor, Tezacaftor, and Elexacaftor
David L. Hughes
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2019)
Heterogeneous catalysts for gas-phase conversion of ethylene to higher olefins
Mohammad Ghashghaee
REVIEWS IN CHEMICAL ENGINEERING (2018)
Advanced Continuous Flow Platform for On-Demand Pharmaceutical Manufacturing
Ping Zhang et al.
CHEMISTRY-A EUROPEAN JOURNAL (2018)
The Emergence and Evolution of Organic Synthesis and Why It is Important to Sustain It as an Advancing Art and Science for Its Own Sake
K. C. Nicolaou
ISRAEL JOURNAL OF CHEMISTRY (2018)
Ir-Catalyzed Borylation as an Efficient Route to a Nicotine Hapten
Janice E. Sieser et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2018)
Process Development of a Suzuki Reaction Used in the Manufacture of Lanabecestat
Ian W. Ashworth et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2018)
Directed Evolution: Bringing New Chemistry to Life
Frances H. Arnold
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2018)
Expanding the Family of Hoveyda-Grubbs Catalysts Containing Unsymmetrical NHC Ligands
Veronica Paradiso et al.
ORGANOMETALLICS (2017)
Biocatalysis in the Pharmaceutical Industry: The Need for Speed
Matthew D. Truppo
ACS MEDICINAL CHEMISTRY LETTERS (2017)
Analysis of Past and Present Synthetic Methodologies on Medicinal Chemistry: Where Have All the New Reactions Gone?
Dean G. Brow et al.
JOURNAL OF MEDICINAL CHEMISTRY (2016)
Olefin Metathesis at the Dawn of Implementation in Pharmaceutical and Specialty-Chemicals Manufacturing
Carolyn S. Higman et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2016)
Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution
Hans Renata et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)
Rules and benefits of Life Cycle Assessment in green chemical process and synthesis design: a tutorial review
Dana Kralisch et al.
GREEN CHEMISTRY (2015)
The Roles Of Patents And Research And Development Incentives In Biopharmaceutical Innovation
Henry G. Grabowski et al.
HEALTH AFFAIRS (2015)
Achieving Continuous Manufacturing: Technologies and Approaches for Synthesis, Workup, and Isolation of Drug Substance May 20-21, 2014 Continuous Manufacturing Symposium
Ian R. Baxendale et al.
JOURNAL OF PHARMACEUTICAL SCIENCES (2015)
Route Design in the 21st Century: The ICSYNTH Software Tool as an Idea Generator for Synthesis Prediction
Anders Bogevig et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2015)
Challenges to achievement of metal sustainability in our high-tech society
Reed M. Izatt et al.
CHEMICAL SOCIETY REVIEWS (2014)
Development of a Grignard-Type Reaction for Manufacturing in a Continuous-Flow Reactor
Fabrice G. J. Odille et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2014)
Directed Evolution: Past, Present, and Future
Ryan E. Cobb et al.
AICHE JOURNAL (2013)
End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation
Salvatore Mascia et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Industrial Applications of the Diels-Alder Reaction
Jacques-Alexis Funel et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2013)
Directed evolution: tailoring biocatalysts for industrial applications
Ashwani Kumar et al.
CRITICAL REVIEWS IN BIOTECHNOLOGY (2013)
En route to full implementation: driving the green chemistry agenda in the pharmaceutical industry
Hans-Juergen Federsel
GREEN CHEMISTRY (2013)
Life cycle assessment in green chemistry: overview of key parameters and methodological concerns
Linda M. Tufvesson et al.
INTERNATIONAL JOURNAL OF LIFE CYCLE ASSESSMENT (2013)
Evolution of a designed retro-aldolase leads to complete active site remodeling
Lars Giger et al.
NATURE CHEMICAL BIOLOGY (2013)
Rendering Schrock-type Molybdenum Alkylidene Complexes Air Stable: User-Friendly Precatalysts for Alkene Metathesis
Johannes Heppekausen et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2011)
Strategy and success for the directed evolution of enzymes
Paul A. Dalby
CURRENT OPINION IN STRUCTURAL BIOLOGY (2011)
Process R&D under the magnifying glass: Organization, business model, challenges, and scientific context
Hans-Jurgen Federsel
BIOORGANIC & MEDICINAL CHEMISTRY (2010)
Enantioselective Synthesis of Sulfoxides: 2000-2009
Elzbieta Wojaczynska et al.
CHEMICAL REVIEWS (2010)
Beyond directed evolution-semi-rational protein engineering and design
Stefan Lutz
CURRENT OPINION IN BIOTECHNOLOGY (2010)
Discovery of Vaniprevir (MK-7009), a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
John A. McCauley et al.
JOURNAL OF MEDICINAL CHEMISTRY (2010)
Biocatalytic Asymmetric Synthesis of Chiral Amines from Ketones Applied to Sitagliptin Manufacture
Christopher K. Savile et al.
SCIENCE (2010)
Continuous flow multi-step organic synthesis
Damien Webb et al.
CHEMICAL SCIENCE (2010)
Chemical Process Research and Development in the 21st Century: Challenges, Strategies, and Solutions from a Pharmaceutical Industry Perspective
Hans-Jurgen Federsel
ACCOUNTS OF CHEMICAL RESEARCH (2009)
Mechanism of the Asymmetric Sulfoxidation in the Esomeprazole Process: Effects of the Imidazole Backbone for the Enantioselection
Muthu Seenivasaperumal et al.
ADVANCED SYNTHESIS & CATALYSIS (2009)
Directed evolution drives the next generation of biocatalysts
Nicholas J. Turner
NATURE CHEMICAL BIOLOGY (2009)
Exploring protein fitness landscapes by directed evolution
Philip A. Romero et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2009)
Optimization and scale-up of a Pd-catalyzed aromatic C-N bond formation:: A key step in the synthesis of a novel 5-HT1B receptor antagonist
Hans-Juergen Federsel et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2008)
Developments in directed evolution for improving enzyme functions
S. Sen et al.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY (2007)
Construction of a chiral central nervous system (CNS)-active aminotetralin drug compound based on a synthesis strategy using multitasking properties of (S)-1-phenylethylamine
Hans-Jurgen Federsel et al.
ACCOUNTS OF CHEMICAL RESEARCH (2007)
Iterative saturation mutagenesis (ISM) for rapid directed evolution of functional enzymes
Manfred T. Reetz et al.
NATURE PROTOCOLS (2007)
Factors influencing the selectivity in asymmetric oxidation of sulfides attached to nitrogen containing heterocycles
Muthu Seenivasaperumal et al.
CHEMICAL COMMUNICATIONS (2007)
Process chemistry: The science, business, logic, and logistics
Tony Y. Zhang
CHEMICAL REVIEWS (2006)
Multiple metal-carbon bonds for catalytic metathesis reactions (Nobel lecture)
Richard R. Schrock
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Olefin-metathesis catalysts for the preparation of molecules and materials (Nobel lecture)
Robert H. Grubbs
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Olefin metathesis: The early days (Nobel lecture)
Y Chauvin
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2006)
Highlights in biocatalysis - Historical landmarks and current trends
UT Bornscheuer et al.
ENGINEERING IN LIFE SCIENCES (2005)
The threshold of toxicological concern concept in risk assessment
R Kroes et al.
TOXICOLOGICAL SCIENCES (2005)
Asymmetry on large scale: The roadmap to stereoselective processes
HJ Federsel
NATURE REVIEWS DRUG DISCOVERY (2005)
Survey of GMP bulk reactions run in a research facility between 1985 and 2002
RW Dugger et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2005)
The metathesis reactions: from a historical perspective to recent developments
D Astruc
NEW JOURNAL OF CHEMISTRY (2005)
Claisen condensation as a facile route to an α-alkoxy-cinnamate:: Synthesis of ethyl (2S)-2-ethoxy-3-(4-hydroxyphenyl)propanoate
MT Linderberg et al.
ORGANIC PROCESS RESEARCH & DEVELOPMENT (2004)
Recent developments in the synthesis and utilization of chiral sulfoxides
I Fernández et al.
CHEMICAL REVIEWS (2003)
Logistics of process R&D: Transforming laboratory methods to manufacturing scale
HJ Federsel
NATURE REVIEWS DRUG DISCOVERY (2003)
A proton-pump inhibitor expedition: The case histories of omeprazole and esomeprazole
L Olbe et al.
NATURE REVIEWS DRUG DISCOVERY (2003)
Molybdenum and tungsten imido alkylidene complexes as efficient olefin-metathesis catalysts
RR Schrock et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2003)
Olefin metathesis: Big-deal reaction
AM Rouhi
CHEMICAL & ENGINEERING NEWS (2002)
Origins, current status, and future challenges of green chemistry
PT Anastas et al.
ACCOUNTS OF CHEMICAL RESEARCH (2002)
Improved biocatalysts by directed evolution and rational protein design
UT Bornscheuer et al.
CURRENT OPINION IN CHEMICAL BIOLOGY (2001)
Asymmetric synthesis of esomeprazole
H Cotton et al.
TETRAHEDRON-ASYMMETRY (2000)
Share Paper
