What enables and blocks synthetic chemistry methods in becoming industrially significant?

What factors will play a role in the decision process when looking at the reasons for certain reactions being adopted for large-scale industrial applications? An examination reveals that there are several parameters that have the power to be influential in this re -gard, either on their own or in combination, all dependent on the circumstances. Seen from a pharmaceutical manufacturing point of view, only certain structural motifs are of interest for in-depth in-vestigations and, hence, are in demand of synthetic methodologies allowing the preparation of quantities beyond what sensibly is achieved by ordinary laboratory procedures. This inevitably leads to many reactions and even reaction types to fall by the wayside. A further criterion to fulfill is that a given synthesis must perform in a robust and consistent manner, irrespective of scale. Many methods used in the laboratory are demanding but can be handled and controlled by scientists well-versed in the art of organic syn-thesis. On scale-up, such reactions could behave in a capricious way, for example under the influence of issues with heat transfer and stirring efficiency, sensitivity to trace amounts of water, or be -ing exposed to a non-inert atmosphere, which could lead to various levels of problems or even complete failure. Another sig-nificant aspect is that a key performance indicator in medicinal chemistry is the capability to make novel chemical compounds amenable to patent protection. This raceinto the unknown will inevitably demand the discovery and development of unprece-dented synthetic methodologies, which eventually will have to prove their capabilities on a larger scale. Finally, in times where green chemistry and sustainability are top-rated criteria for any chemical process, there is bound to be a major reluctance to apply procedures that cannot guarantee the highest level of environ-mental concern for both ethical and legal reasons.

Automated summary

Several factors, such as the specific structural motifs of interest, the ability to perform consistently on a larger scale, the need for novel synthetic methodologies, and the requirement for environmental concern, play a role in the decision process for adopting certain reactions for industrial applications.