Journal
NEUROSURGICAL FOCUS
Volume 41, Issue 3, Pages -Publisher
AMER ASSOC NEUROLOGICAL SURGEONS
DOI: 10.3171/2016.7.FOCUS16194
Keywords
NPH; theories; DTI; imaging
Categories
Funding
- Joint Royal College of Surgeons of England
- Dunhill Medical Trust Fellowship
- Tunku Abdul Rahman Centenary Grant
- National Medical Research Council Transition Award Grant, Singapore
- Medical Research Council Programme Grant (Wolfson Brain Imaging Centre Cooperative)
- Johnson and Johnson-Codman
- Integra
- Sophysa
- Aesculap
- NIHR Senior Investigator Award
- Medical Research Council Programme grant
- NIHR Cambridge Biomedical Research Centre grant
- Medical Research Council [G0001237, G0600986, G9439390] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0508-10327] Funding Source: researchfish
- MRC [G0600986, G0001237, G9439390] Funding Source: UKRI
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The pathophysiology of NPH continues to provoke debate. Although guidelines and best-practice recommendations are well established, there remains a lack of consensus about the role of individual imaging modalities in characterizing specific features of the condition and predicting the success of CSF shunting. Variability of clinical presentation and imperfect responsiveness to shunting are obstacles to the application of novel imaging techniques. Few studies have sought to interpret imaging findings in the context of theories of NPH pathogenesis. In this paper, the authors discuss the major streams of thought for the evolution of NPH and the relevance of key imaging studies contributing to the understanding of the pathophysiology of this complex condition.
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