Journal
CHEMICO-BIOLOGICAL INTERACTIONS
Volume 231, Issue -, Pages 1-9Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.cbi.2015.02.004
Keywords
Pyrazolone-based derivative; Cadmium; Eca-109 cells; Apoptosis; Mitochondrial pathway
Funding
- Science Foundation of Xinjiang [2013211A018]
- Graduate Research and Innovation Project of Xinjiang [XJGRI2013043]
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Pyrazolone complexes have strong bio-activity but the anti-tumor mechanism of pyrazolone-based metal complexes is not fully understood. In this study, the inhibitory effect and possible mechanism of a novel pyrazolone-based derivative compound (Cd-PMPP-SAL) on human esophageal cancer cells were investigated. We found that Cd-PMPP-SAL inhibited the proliferation of Eca-109 cells in a dose-dependent manner and induced the apoptosis in the cells. Interestingly, Cd-PMPP-SAL promoted the production of ROS, loss of mitochondrial membrane potential, PARP cleavage and activation of caspase-3/9. These results suggest Cd-PMPP-SAL-induced apoptosis might be mediated by the increased production of ROS and caspase-dependent mitochondria-mediated pathway. These results suggest that Cd-PMPP-SAL is a potential candidate for the treatment of esophageal cancer. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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