Journal
NEUROSCIENTIST
Volume 23, Issue 5, Pages 542-553Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858416679936
Keywords
dopamine; amygdala; neural circuits; synaptic plasticity; posttraumatic stress disorder (PTSD)
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Funding
- National Research Foundation of Korea [2014051826, 2015R1A2A1A15054037, 2015M3C7A1027351]
- National Research Foundation of Korea [2015R1A2A1A15054037, 2015M3C7A1027351] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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In addition to modulating a number of cognitive functions including reward, punishment, motivation, and salience, dopamine (DA) plays a pivotal role in regulating threat-related emotional memory. Changes in neural circuits of the amygdala nuclei are also critically involved in the acquisition and expression of emotional memory. In this review, we summarize the regulation of amygdala circuits by DA. Specifically, we describe DA signaling in the amygdala, and DA regulation of synaptic transmission and synaptic plasticity of the amygdala neurons. Finally, we discuss a potential contribution of DA-related mechanisms to the pathogenesis of posttraumatic stress disorder.
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