Journal
NEUROSCIENCE RESEARCH
Volume 102, Issue -, Pages 47-55Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neures.2014.08.012
Keywords
Fatty acid binding protein; Polyunsaturated fatty acids; Psychiatric disorders; Prepulse inhibition; Acoustic startle reflex; Neurogenesis
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Funding
- CREST Elucidation of Mechanisms Underlying Brain Development and Learning from the Japanese Science and Technology Corporation
- Grants-in-Aid for Scientific Research [15K12764] Funding Source: KAKEN
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The brain is rich in lipid and fatty molecules. In this review article, we focus on fatty acid binding proteins (Fabps) that bind to fatty acids such as arachidonic acid and docosahexianoic acid and transfer these lipid ligands within the cytoplasm. Among Fabp family molecules, Fabp3, Fabp5, and Fabp7 are specifically localized in neural stem/progenitor cells, neurons and glia in a cell-type specific manner. Quantitative trait locus analysis has revealed that Fabp7 is related with performance of prepulse inhibition (PPI) that is used as an endophenotype of psychiatric diseases such as schizophrenia. Fabp5 and Fabp7 play important roles on neurogenesis and differentially regulate acoustic startle response and PPI. However, other behavior performances including spatial memory, anxiety-like behavior, and diurnal changes in general activity were not different in mice deficient for Fabp7 or Fabp5. Considering the importance of fatty acids in neurogenesis, we would like to emphasize that lipid nutrition and its dynamism via Fabps play significant roles in mental conditions. This might provide a good example of how nutritional environment can affect psychiatric conditions at the molecular level. (C) 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
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