Journal
NEUROSCIENCE LETTERS
Volume 611, Issue -, Pages 116-122Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2015.11.037
Keywords
Anesthesia; Isoflurane; Functional MRI; Dose-dependent effect
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Funding
- National Natural Science Foundation [81222018, 81371527]
- Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) of China [IRT1272]
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The dose-dependent effect of isoflurane on cerebral regional activity and functional connectivity (FC) in 14 rhesus monkeys was investigated using resting-state functional MRI. Amplitude of low-frequency fluctuations (ALFF) decreased in the cerebellum, visual cortex, and cortico-subcortical network when the isoflurane dose changed from 1.0 to 1.3 MAC. ALFF decreased in the arousal system, cerebellum, sensory, visual areas, cortico-subcortical network and default mode network and increased in the bilateral dorsal prefrontal cortices, frontal eye fields and motor-related areas from 1.0 to 1.6 MAC. FC of the default mode network, frontal-parietal, cortico-subcortical, motor, sensory, auditory and visual areas was reduced when isoflurane increased from 1.0 to 1.3 MAC. FC decreased in more widespread areas, especially in regions of cortico-subcortical networks and limbic systems, when isoflurane further increased from 1.0 to 1.6 MAC. Both dose-dependent decreased and increased ALFF were separately observed, while FC deteriorated as the anesthesia deepened. These results suggest that changes continue to occur past the loss of consciousness, and the dose-dependent effects of isoflurane are different with regard to regional function and neural network integration. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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