Journal
NEUROSCIENCE LETTERS
Volume 612, Issue -, Pages 104-109Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2015.11.048
Keywords
Parkinson's disease; Pinocembrin; MPP+; Heme oxygenase-1; Neuroprotection
Categories
Funding
- National Natural Science Foundation of China [81450036, 81260196]
- China Postdoctoral Science Foundation [2015M570974]
- Program for Young Talents of Science and Technology in Universities of Inner Mongolia Autonomous Region (IMAR) [NJYT-13-B20]
- Program for Young Innovative Talents of IMAR
- New Century 321 Talents Project of IMAR
- Talent development fund of IMAR
- Natural Science Foundation of IMAR [2014MS0892, 2014BS0802, 2014MS0814, 2015BS0812, 2013MS1176]
- National Social Science Foundation of China [13CRK009]
- Scientific Research Projects in Universities of IMAR [NJZY234, NJZZ12306, NJZZ14271]
- Program of IMAR Key Laboratory of Human Genetics
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Our recent study demonstrated that pinocembrin (PB), the most abundant flavonoid in propolis, has neuroprotective effect against 1-methyl-4-phenylpyridinium (MPP+)-induced SH-SY5Y neurotoxicity. However, the mechanism as how PB can induce neuroprotection is not known. In the present study, we demonstrate here that PB increased heme oxygenase-1 (HO-1) expression, which conferred protection against MPP+-induced cytotoxicity, because the inhibitor of HO-1 zinc protoporphyrin-IX attenuated the neuroprotection of PB. PB induced the phosphorylation of ERK1/2, and its cytoprotective effect was abolished by ERK1/2 inhibitors. Meanwhile, we have shown that MPP+ induce the expression in a concentration-dependent manner in SH-SY5Y cells, which was further enhanced by PB. Taken together, the results suggest that PB enhances HO-1 expression to suppress MPP+-induced oxidative damage via ERK1/2 signaling pathways. These results revealed the mechanisms of PB enhances HO-1 expression, and contribute to shed some light on the mechanisms whereby PB inhibits the MPP+-induced neurotoxicity. These data indicated that PB might provide a valuable therapeutic strategy for the treatment of PD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
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