Journal
NEUROSCIENCE LETTERS
Volume 626, Issue -, Pages 112-118Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.neulet.2016.05.029
Keywords
Intermittent hypoxia; Leptin; Arcuate nucleus of the hypothalamus; Body energy balance; Pro-opiomelanocortin; Signal transducer and activator of transcription 3
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Funding
- Ontario Graduate Scholarship
- Heart and Stroke Foundation of Ontario [NA6433]
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Intermittent hypoxia (IH) is a major pathophysiological consequence of obstructive sleep apnea. Recently, it has been shown that IH results in changes in body energy balance, leptin secretion and concomitant alterations in arcuate nucleus (ARC). In this study, the role of leptin on these changes was investigated in leptin-deficient rats exposed to IH or normoxic control conditions. Body weights, consumatory and locomotor behaviours, and protein signaling in ARC were assessed immediately after IH exposure. Compared to normoxia, IH altered body weight, food intake, locomotor pattern, and the plasma concentration of leptin and angiotensin II in the wild-type rat. However, these changes were not observed in the leptin-deficient rat. Within ARC of wild-type animals, IH increased phosphorylated signal transducer and activator of transcription 3 and pro-opiomelanocortin protein expression, but not in the leptin-deficient rat. The long-form leptin receptor protein expression was not altered following IH in either rat strain. These data suggest that leptin is involved in mediating the alterations to body energy balance and ARC activity following IH. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
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