Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 69, Issue -, Pages 36-48Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2016.07.020
Keywords
Addiction; Methamphetamine; Cognitive deficits; Prefrontal; Perirhinal; Glutamate; Attention; Object recognition
Categories
Funding
- NIH/NIDA [R01DA033049]
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Methamphetamine (meth) is one of the most abused substances worldwide. Chronic use has been associated with repeated relapse episodes that may be exacerbated by cognitive impairments during drug abstinence. Growing evidence demonstrates that meth compromises prefrontal cortex activity, resulting in persisting attentional and memory impairments. After summarizing recent studies of meth-induced cognitive dysfunction using a translationally relevant model of self-administered meth, this review emphasizes the cortical brain changes contributing to cognitive dysregulation during abstinence. Finally, we propose the use of cognitive enhancers during abstinence that may promote a drug-free state by reversing cortical dysfunction linked with prolonged meth abuse. (C) 2016 Elsevier Ltd. All rights reserved.
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