Journal
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
Volume 62, Issue -, Pages 35-47Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neubiorev.2015.12.014
Keywords
Epilepsy; GABA-ergic interneurons; Lateral ganglionic eminence; Medial ganglionic eminence; Neural cell grafts; Pain; Schizophrenia; Stem cell therapy; Temporal lobe epilepsy
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Funding
- Department of Defense (PRMRP award) [W81XWH-14-1-0558]
- Department of Veterans Affairs (VA Merit Award) [I01 BX002351]
- National Institute of Neurological Disorders and Stroke [R01 NS054780]
- State of Texas
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Diminution in the number of gamma-amino butyric acid positive (GABA-ergic) interneurons and their axon terminals, and/or alterations in functional inhibition are conspicuous brain alterations believed to contribute to the persistence of seizures in acquired epilepsies such as temporal lobe epilepsy. This has steered a perception that replacement of lost GABA-ergic interneurons would improve inhibitory synaptic neurotransmission in the epileptic brain region and thereby reduce the occurrence of seizures. Indeed, studies using animal prototypes have reported that grafting of GABA-ergic progenitors derived from multiple sources into epileptic regions can reduce seizures. This review deliberates recent advances, limitations and challenges concerning the development of GABA-ergic cell therapy for epilepsy. The efficacy and limitations of grafts of primary GABA-ergic progenitors from the embryonic lateral ganglionic eminence and medial ganglionic eminence (MGE), neural stem/progenitor cells expanded from MGE, and MGE-like progenitors generated from human pluripotent stem cells for alleviating seizures and co-morbidities of epilepsy are conferred. Additional studies required for possible clinical application of GABA-ergic cell therapy for epilepsy are also summarized. Published by Elsevier Ltd.
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