Journal
NEUROSCIENCE
Volume 321, Issue -, Pages 99-107Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2015.12.061
Keywords
DISC1; mouse models; psychiatry
Categories
Funding
- NIH [MH-084018, MH-094268, MH-069853, MH-085226, MH-088753, MH-092443]
- Stanley
- S-R
- RUSK
- NARSAD
- Maryland Stem Cell Research Fund
- DOD/CDMRP [W81XWH-11-1-0269]
- Takeda Pharmaceutical Co. Ltd at the Kyoto University
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We have seen an era of explosive progress in translating neurobiology into etiological understanding of mental disorders for the past 10-15 years. The discovery of Disrupted-in-schizophrenia 1 (DISC1) gene was one of the major driving forces that have contributed to the progress. The finding that DISC1 plays crucial roles in neuro-development and synapse regulation clearly underscored the utility and validity of DISC1-related biology in advancing our understanding of pathophysiological processes underlying psychiatric conditions. Despite recent genetic studies that failed to identify DISC1 as a risk gene for sporadic cases of schizophrenia, DISC1 mutant mice, coupled with various environmental stressors, have proven successful in satisfying face validity as models of a wide range of human psychiatric conditions. Investigating mental disorders using these models is expected to further contribute to the circuit-level understanding of the pathological mechanisms, as well as to the development of novel therapeutic strategies in the future. This article is part of a Special Issue entitled: Neuropsychiatric Disease. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
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