Journal
NEUROSCIENCE
Volume 323, Issue -, Pages 43-61Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2015.04.001
Keywords
synaptic plasticity; astrocyte; gliotransmission
Categories
Funding
- Maria Sklodowska-Curie International Outgoing Fellowship [331486]
- ERC [340368]
- Swiss National Science Foundation (SNSF) [31003A-140999]
- NCCR Synapsy''
- NCCR Transcure
- Swiss National Science Foundation (SNF) [31003A_140999] Funding Source: Swiss National Science Foundation (SNF)
- European Research Council (ERC) [340368] Funding Source: European Research Council (ERC)
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Synaptic plasticity is the capacity of a preexisting connection between two neurons to change in strength as a function of neural activity. Because synaptic plasticity is the major candidate mechanism for learning and memory, the elucidation of its constituting mechanisms is of crucial importance in many aspects of normal and pathological brain function. In particular, a prominent aspect that remains debated is how the plasticity mechanisms, that encompass a broad spectrum of temporal and spatial scales, come to play together in a concerted fashion. Here we review and discuss evidence that pinpoints to a possible non-neuronal, glial candidate for such orchestration: the regulation of synaptic plasticity by astrocytes. This article is part of a Special Issue entitled: Astrocyte-Neuron Interact. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
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