Journal
NEUROSCIENCE
Volume 323, Issue -, Pages 207-221Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuroscience.2015.04.035
Keywords
pannexin1; connexin43; astrocytes; neurodegeneration
Categories
Funding
- Canadian Stroke Network Summer Studentship Program
- Heart and Stroke Foundation of Canada
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The World Health Organization has predicted that by 2040 neurodegenerative diseases will overtake cancer to become the world's second leading cause of death after cardiovascular disease. This has sparked the development of several European and American brain research initiatives focusing on elucidating the underlying cellular and molecular mechanisms of neurodegenerative diseases. Connexin (Cx) and pannexin (Panx) membrane channel proteins are conduits through which neuronal, glial, and vascular tissues interact. In the brain, this interaction is highly critical for homeostasis and brain repair after injury. Understanding the molecular mechanisms by which these membrane channels function, in health and disease, might be particularly influential in establishing conceptual frameworks to develop new therapeutics against Cx and Panx channels. This review focuses on current insights and emerging concepts, particularly the impact of connexin43 and pannexin1, under neuroprotective and neurodegenerative conditions within the context of astrocytes. This article is part of a Special Issue entitled: Astrocyte-Neuron Interact. Crown Copyright (C) 2015 Published by Elsevier Ltd. on behalf of IBRO. All rights reserved.
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