Journal
NEUROREPORT
Volume 27, Issue 7, Pages 501-507Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/WNR.0000000000000570
Keywords
anti-inflammation; hippocampus; kainic acid; lidocaine; neuroprotection
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Funding
- Far Eastern Memorial Hospital, Taiwan, Republic of China [FEMH-2015-D-001]
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Lidocaine, the most commonly used local anesthetic, inhibits glutamate release from nerve terminals. Given the involvement of glutamate neurotoxicity in the pathogenesis of various neurological disorders, this study investigated the role of lidocaine in hippocampal neuronal death and inflammatory events induced by an i.p. injection of kainic acid (KA) (15 mg/kg), a glutamate analog. The results showed that KA significantly led to neuronal death in the CA3 pyramidal layers of the hippocampus and this effect was attenuated by the systemic administration of lidocaine (0.8 or 4 mg/kg, i.p.) 30 min before KA injection. Moreover, KA-induced microglia activation and gene expression of proinflammatory cytokines, namely, interleukin-1 beta, interleukin-6, and tumor necrosis factor-alpha, in the hippocampus were reduced by the lidocaine pretreatment. Altogether, the results suggest that lidocaine can effectively treat glutamate excitotoxicity-related brain disorders. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
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