Journal
JOURNAL OF FUNCTIONAL BIOMATERIALS
Volume 14, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/jfb14090436
Keywords
metal-phenolic networks; GSH-activatable; photothermal therapy; chemodynamic therapy; chemotherapy
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A novel GSH-activatable Cu2+-Quercetin network loaded with Au nanoparticles and DOX was synthesized for the synergistic therapy of chemotherapy enhanced by chemotherapy and photothermal therapy. The multi-mode synergistic strategy showed excellent therapeutic effects in cancer cells.
Chemotherapy (CT) plays an important role in the antitumor process, but the unsatisfactory therapeutic efficacy and the obvious toxic side effects of CT seriously restrict its application. To overcome the limitations of CT, the strategy of chemotherapy enhanced by chemodynamic therapy (CDT) and photothermal therapy (PTT) has been considered a promising approach to improve the anticancer effect. Herein, a novel GSH-activatable Cu2+-Quercetin network (QC) was synthesized via a convenient strategy to load Au nanoparticles (NPs) and DOX, named QCDA, for the synergistic therapy of CT/CDT/PTT. The results showed that QCDA exhibited GSH-sensitive degradation and cargos release in cancer cells, and then PTT and CDT caused by Au NPs and Cu+ significantly enhanced the CT effect of DOX and Quercetin on anticancer. More importantly, the PTT and depleted GSH accelerated the Fenton-like ionization process resulting in facilitating the CDT efficiency. Collectively, the multi-mode synergistic strategy of CT/CDT/PTT, which showed an excellent therapeutic effect, maybe a potential therapeutic pathway for anticancer.
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