Journal
CHEMICAL SOCIETY REVIEWS
Volume 44, Issue 14, Pages 4953-4972Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cs00030k
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Funding
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [25620133, 25220207, 26102529, 26.794]
- CREST from JST
- Grants-in-Aid for Scientific Research [26102529, 15K12754] Funding Source: KAKEN
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Fluorescence imaging techniques have been widely used to visualize biological molecules and phenomena. In particular, several studies on the development of small-molecule fluorescent probes have been carried out, because their fluorescence properties can be easily tuned by synthetic chemical modification. For this reason, various fluorescent probes have been developed for targeting biological components, such as proteins, peptides, amino acids, and ions, to the interior and exterior of cells. In this review, we cover advances in the development of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene (BODIPY)-based fluorescent probes for biological studies over the past decade.
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