4.8 Review

Biosensing by luminogens with aggregation-induced emission characteristics

Journal

CHEMICAL SOCIETY REVIEWS
Volume 44, Issue 13, Pages 4228-4238

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cs00325j

Keywords

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Funding

  1. National Basic Research Program of China (973 Program) [2013CB834701]
  2. Research Grants Council of Hong Kong [604711, 603509, 602212, N_HKUST620/11]
  3. University Grants Committee of Hong Kong [AoE/P-03/08, T23-713/11-1]
  4. Guangdong Innovative Research Team Program [201101C0105067115]

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Fluorescent biosensors are powerful analytical tools for studying biological events in living systems. Luminescent materials with aggregation-induced emission (AIE) attributes have attracted much research interest and have been identified as a novel class of luminogens to develop fluorescent turn-on biosensors with superior sensitivity. In this Tutorial Review, we present an overview of the AIE phenomenon and its mechanism. We summarize the structural design and working principle of AIE biosensors developed recently. Typical examples of AIE biosensors are presented.

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