Journal
CHEMICAL SOCIETY REVIEWS
Volume 44, Issue 14, Pages 4547-4595Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cs00372a
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Funding
- Australian Research Council [ARC DP140100227]
- Strategic Research Centre for Chemistry and Biotechnology (Deakin University)
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The ability to spatiotemporally identify the formation of specific anionic species, or track changes in their concentration inside living systems, is of critical importance in deciphering their exact biological roles and effects. The development of probes (also called bioimaging agents and intracellular sensors) to achieve this goal has become a rapidly growing branch of supramolecular chemistry. In this critical review the challenges specific to the task are identified and for a select range of small anions of environmental and biological relevance (fluoride, chloride, iodide, cyanide, pyrophosphate, bicarbonate, hydrosulphide, peroxynitrite, hypochlorite and hypobromite) a comprehensive overview of the currently available in vitro and in vivo probes is provided.
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