Journal
GENES & DISEASES
Volume 10, Issue 6, Pages 2331-2338Publisher
KEAI PUBLISHING LTD
DOI: 10.1016/j.gendis.2022.04.018
Keywords
Biosynthetic pathway; Cancer; de novo synthesis; Metabolism; Nucleotide
Ask authors/readers for more resources
The de novo nucleotide biosynthetic pathway is a highly conserved and crucial biochemical pathway found in almost all organisms. Dysregulation of this pathway has been linked to the development of many human diseases, including cancer. In this review, the authors provide a comprehensive overview of the pathway, its regulatory mechanisms, its role in tumorigenesis, and potential targeting opportunities.
De novo nucleotide biosynthetic pathway is a highly conserved and essential biochemical pathway in almost all organisms. Both purine nucleotides and pyrimidine nucleotides are necessary for cell metabolism and proliferation. Thus, the dysregulation of the de novo nucleotide biosynthetic pathway contributes to the development of many human diseases, such as cancer. It has been shown that many enzymes in this pathway are overactivated in different cancers. In this review, we summarize and update the current knowledge on the de novo nucleotide biosynthetic pathway, regulatory mechanisms, its role in tumorigenesis, and potential targeting opportunities. & COPY; 2022 The Authors. Publishing services by Elsevier B.V. on behalf of KeAi Communications Co., Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons. org/licenses/by-nc-nd/4.0/).
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available