Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 357, Issue 12, Pages 2721-2727Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500346
Keywords
C(sp(3))-C(sp(2)) bond formation; 2,2-difluoroethylation; nickel catalyst; Suzuki cross-coupling; 2,2,2-trifluoroethylation
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Funding
- National Natural Science Foundation of China [81321092]
- SKLDR/SIMM [SIMM1403ZZ-01]
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An efficient alkylation method of functionalized alkyl halides under mild nickel-catalyzed C(sp(3))-C(sp(2)) Suzuki cross-coupling conditions is described. The features of this approach are excellent functional group compatibility, low cost nickel catalyst, and the use of a mild base. This is also the first successful example of the nickel-catalyzed direct 2,2-difluoroethylation or 2,2,2-trifluoroethylation of aryl-/heteroarylboronic acids.
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