Journal
NEUROPHARMACOLOGY
Volume 104, Issue -, Pages 76-81Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuropharm.2015.08.042
Keywords
Neuropathic pain; Microglia; Purinergic receptors; Transcription factors; Proinflammatory cytokines; Chemokines; Spinal cord
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Funding
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Japan Science and Technology Agency (JST) through Core Research for Evolutional Science and Technology (CREST) program
- Takeda Science Foundation
- Toray Science Foundation
- Grants-in-Aid for Scientific Research [221S0003, 15H02522] Funding Source: KAKEN
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Neuropathic pain, a chronic pain condition following nerve damage and degeneration, involves aberrant excitability in the dorsal horn of the spinal cord. A growing body of evidence has shown that the aberrant excitability might not be a consequence merely of changes in neurons, but rather of multiple alterations in glial cells, such as microglia, the immune cells of the central nervous system. Extracellular nucleotides play an important role in neuron-microglia communication through purinergic P2X and P2Y receptors expressed in microglia. Importantly, inhibiting the function or expression of these microglial molecules suppresses aberrant excitability of dorsal horn neurons and neuropathic pain, suggesting a crucial role for microglial purinergic signaling in mechanisms of neuropathic pain. Here, we describe recent advances in the understanding of neuron microglia interactions by purinergic signaling in neuropathic pain following neurodegeneration. (C) 2015 Elsevier Ltd. All rights reserved.
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