Journal
CHEMICAL SOCIETY REVIEWS
Volume 44, Issue 1, Pages 91-102Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cs00246f
Keywords
-
Categories
Funding
- European Union
- Engineering and Physical Sciences Research Council
- Biotechnology and Biological Sciences Research Council
- Medical Research Council
- Wellcome Trust
- Cambridge Trusts
- EPSRC [EP/J016012/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/J016012/1] Funding Source: researchfish
Ask authors/readers for more resources
Peptide stapling is a strategy for constraining short peptides typically in an alpha-helical conformation. Stapling is carried out by covalently linking the side-chains of two amino acids, thereby forming a peptide macrocycle. There is an expanding repertoire of stapling techniques based on different macrocyclisation chemistries. In this tutorial review, we categorise and analyse key examples of peptide stapling in terms of their synthesis and applicability to biological systems.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available