Journal
CHEMICAL SOCIETY REVIEWS
Volume 44, Issue 15, Pages 5265-5290Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cs00025d
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Funding
- Ministry of Science and Technology of China [2012AA02A701, 2013CB733600]
- National Natural Science Foundation of China [21390203]
- National Institutes of Health [GM077596]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM077596] Funding Source: NIH RePORTER
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Natural products produced by microorganisms and plants are a major resource of antibacterial and anticancer drugs as well as industrially useful compounds. However, the native producers often suffer from low productivity and titers. Here we summarize the recent applications of heterologous biosynthesis for the production of several important classes of natural products such as terpenoids, flavonoids, alkaloids, and polyketides. In addition, we will discuss the new tools and strategies at multi-scale levels including gene, pathway, genome and community levels for highly efficient heterologous biosynthesis of natural products.
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