Journal
CHEMICAL SOCIETY REVIEWS
Volume 44, Issue 14, Pages 4769-4791Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cs00323c
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Funding
- US National Science Foundation [CHE-0911092]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1506942] Funding Source: National Science Foundation
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Neither palladium nor platinum is an endogenous biological metal. Imaging palladium in biological samples, however, is becoming increasingly important because bioorthogonal organometallic chemistry involves palladium catalysis. In addition to being an imaging target, palladium has been used to fluorometrically image biomolecules. In these cases, palladium species are used as imaging-enabling reagents. This review article discusses these fluorometric methods. Platinum-based drugs are widely used as anticancer drugs, yet their mechanism of action remains largely unknown. We discuss fluorometric methods for imaging or quantifying platinum in cells or biofluids. These methods include the use of chemosensors to directly detect platinum, fluorescently tagging platinum-based drugs, and utilizing post-labeling to elucidate distribution and mode of action.
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