Journal
NEURON
Volume 91, Issue 6, Pages 1342-1355Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2016.08.008
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Funding
- EU-FP7-ERC [337075]
- Momentum Program of the Hungarian Academy of Sciences [LP2013-62/2013]
- Simons Foundation
- Fundacion La Caixa
- EMBO [ALTF 147-2015]
- [NIHMH54671]
- [MH107396]
- [NS 090583]
- European Research Council (ERC) [337075] Funding Source: European Research Council (ERC)
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Sharp-wave ripples (SPW-Rs) in the hippocampus are implied in memory consolidation, as shown by observational and interventional experiments. However, the mechanism of their generation remains unclear. Using two-dimensional silicon probe arrays, we investigated the propagation of SPW-Rs across the hippocampal CA1, CA2, and CA3 subregions. Synchronous activation of CA2 ensembles preceded SPW-R-related population activity in CA3 and CA1 regions. Deep CA2 neurons gradually increased their activity prior to ripples and were suppressed during the population bursts of CA3-CA1 neurons (ramping cells). Activity of superficial CA2 cells preceded the activity surge in CA3-CA1 (phasic cells). The trigger role of the CA2 region in SPW-R was more pronounced during waking than sleeping. These results point to the CA2 region as an initiation zone for SPW-Rs.
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