4.8 Review

Stability enhancement of fluorophores for lighting up practical application in bioimaging

Journal

CHEMICAL SOCIETY REVIEWS
Volume 44, Issue 13, Pages 4179-4184

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cs00152d

Keywords

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Funding

  1. National 973 Program [2013CB733700]
  2. NSFC [21325625]
  3. NSFC/China [21421004, 21176075]
  4. Oriental Scholarship, National Major Scientific Technological Special Project [2012YQ15008709]
  5. SRFDP [20120074110002]
  6. Fundamental Research Funds for the Central Universities [WK1013002]

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The practical application of organic fluorophores in bioimaging is severely limited due to their generally poor stability. In this Highlight, we emphasize several representative strategies including nanoparticle-encapsulating dyes, dye-doped nanoparticles and molecular engineering for stabilizing fluorophores, especially with a breakthrough in photostability for visualizing disease therapy, tumor and biological processes.

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