Journal
NEURON
Volume 90, Issue 1, Pages 11-25Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2016.02.033
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Funding
- Foundation for Dystonia Research
- Fonds voor Wetenschappelijk Onderzoek
- European Research Council
- Methusalem grant of the Flemish government
- Hercules foundation
- Belgian Science Policy
- KU Leuven
- Opening the Future (Leuvens Universiteitsfonds)
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Lipids are the most abundant organic compounds in the brain. The brain has a unique lipidome, and changes in lipid concentration, organization, and metabolism are associated with many neuronal diseases. Here, we discuss recent advances in understanding presynaptic membrane lipid organization, centered on illustrative examples of how the lipids themselves regulate membrane trafficking and control protein activity. This insight highlights that presynaptic terminals are membrane-remodeling machines and that cooperation between lipid and protein molecules underlies presynaptic activity.
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