Journal
NEURON
Volume 92, Issue 2, Pages 544-554Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2016.09.018
Keywords
-
Categories
Funding
- NeuroVentures - BIoX
- Stanford Neurosciences Institute
- National Health and Medical Research Council [GNT1072403]
- National Institute of Drug Administration [F32DA041773]
Ask authors/readers for more resources
Higher brain function relies upon the ability to flexibly integrate information across specialized communities of brain regions; however, it is unclear how this mechanism manifests over time. In this study, we used time-resolved network analysis of fMRI data to demonstrate that the human brain traverses between functional states that maximize either segregation into tight-knit communities or integration across otherwise disparate neural regions. Integrated states enable faster and more accurate performance on a cognitive task, and are associated with dilations in pupil diameter, suggesting that ascending neuromodulatory systems may govern the transition between these alternative modes of brain function. Together, our results confirm a direct link between cognitive performance and the dynamic reorganization of the network structure of the brain.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available