Journal
CHEMICAL SOCIETY REVIEWS
Volume 44, Issue 17, Pages 6258-6286Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cs00511b
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Funding
- National Nature Science Foundation of China [51102259, 31271021, 31222023]
- Distinguished Young Scholars of Sichuan University [2011SCU04B18]
- Intramural Research Program, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health
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Metastasis is deadly and also tough to treat as it is much more complicated than the primary tumour. Anti-metastasis approaches available so far are far from being optimal. A variety of nanomedicine formulae provide a plethora of opportunities for developing new strategies and means for tackling metastasis. It should be noted that individualized anti-metastatic nanomedicines are different from common anti-cancer nanomedicines as they specifically target different populations of malignant cells. This review briefly introduces the features of the metastatic cascade, and proposes a series of nanomedicine-based anti-metastasis strategies aiming to block each metastatic step. Moreover, we also concisely introduce the advantages of several promising nanoparticle platforms and their potential for constructing state-of-the-art individualized anti-metastatic nanomedicines.
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