Journal
NEURON
Volume 90, Issue 2, Pages 374-387Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2016.03.007
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Funding
- National Institute of Mental Health [MH085499]
- National Institute of Neurological Disorders and Stroke [NS058668, NS077986, BRAIN NS0905905]
- National Science Foundation [BRAIN EAGER 1451026]
- Japan Society for the Promotion of Science [23135519, 24500409]
- Canadian Institutes of Health Research [MT-5877]
- US-Israeli Binational Foundation [2011432]
- Grants-in-Aid for Scientific Research [24500409, 23135519] Funding Source: KAKEN
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Sniffing and whisking typify the exploratory behavior of rodents. These actions involve separate oscillators in the medulla, located respectively in the pre-Botzinger complex (preBotC) and the vibrissa-related region of the intermediate reticular formation (vIRt). We examine how these oscillators synergize to control sniffing and whisking. We find that the vIRt contains glycinergic/GABAergic cells that rhythmically inhibit vibrissa facial motoneurons. As a basis for the entrainment of whisking by breathing, but not vice versa, we provide evidence for unidirectional connections from the preBotC to the vIRt. The preBotC further contributes to the control of the mystacial pad. Lastly, we show that bilateral synchrony of whisking relies on the respiratory rhythm, consistent with commissural connections between preBotC cells. These data yield a putative circuit in which the preBotC acts as a master clock for the synchronization of vibrissa, pad, and snout movements, as well as for the bilateral synchronization of whisking.
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