Journal
NEURON
Volume 89, Issue 5, Pages 956-970Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2016.01.034
Keywords
-
Categories
Funding
- Dr. Miriamand Sheldon G. Adelson Medical Research Foundation
- NINDS Informatics Center for Neurogenetics and Neurogenomics [P30 NS062691]
- NIH [R01 NS038253, NS074430]
- Bertarelli Foundation
Ask authors/readers for more resources
The regenerative capacity of the injured CNS in adult mammals is severely limited, yet axons in the peripheral nervous system (PNS) regrow, albeit to a limited extent, after injury. We reasoned that coordinate regulation of gene expression in injured neurons involving multiple pathways was central to PNS regenerative capacity. To provide a framework for revealing pathways involved in PNS axon regrowth after injury, we applied a comprehensive systems biology approach, starting with gene expression profiling of dorsal root ganglia (DRGs) combined with multi-level bioinformatic analyses and experimental validation of network predictions. We used this rubric to identify a drug that accelerates DRG neurite outgrowth in vitro and optic nerve outgrowth in vivo by inducing elements of the identified network. The work provides a functional genomics foundation for understanding neural repair and proof of the power of such approaches in tackling complex problems in nervous system biology.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available