Real-World Evidence Analysis of a Hybrid Closed-Loop System

Article Endocrinology & Metabolism

Hybrid Closed-Loop with Faster Insulin Aspart Compared with Standard Insulin Aspart in Very Young Children with Type 1 Diabetes: A Double-Blind, Multicenter, Randomized, Crossover Study

Julia Ware et al.

Summary: This study evaluated the use of hybrid closed-loop (HCL) insulin delivery with faster insulin aspart (Fiasp) in very young children with type 1 diabetes (T1D). The results showed that there was no significant difference in glycemic control between HCL with Fiasp and standard insulin aspart (IAsp) in children aged 2-6 years with T1D.

DIABETES TECHNOLOGY & THERAPEUTICS (2023)

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Review Endocrinology & Metabolism

Consensus Recommendations for the Use of Automated Insulin Delivery Technologies in Clinical Practice

Moshe Phillip et al.

Summary: The global prevalence of diabetes continues to be a challenge and the advances in automated insulin delivery (AID) technologies have shown to be safe and effective in helping patients achieve their glycemic goals. However, there is a lack of guidance for clinicians on using AID systems in clinical settings.

ENDOCRINE REVIEWS (2023)

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Article Endocrinology & Metabolism

Improvements in Glycemic Outcomes in 4738 Children, Adolescents, and Adults with Type 1 Diabetes Initiating a Tubeless Insulin Management System

Grazia Aleppo et al.

Summary: This study analyzed real-world outcomes of a large cohort of people living with type 1 diabetes using the Omnipod DASH System, which showed significant improvement in HbA1c and a substantial reduction in hypoglycemic events after 3 months of use.

DIABETES THERAPY (2023)

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Article Medicine, General & Internal

Randomized Trial of Closed-Loop Control in Very Young Children with Type 1 Diabetes

J. Ware et al.

Summary: Hybrid closed-loop therapy significantly improves glycemic control in very young children with type 1 diabetes without increasing the time spent in hypoglycemia.

NEW ENGLAND JOURNAL OF MEDICINE (2022)

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Article Endocrinology & Metabolism

Comparison of MiniMed 780G system performance in users aged younger and older than 15 years: Evidence from 12 870 real-world users

Arcelia Arrieta et al.

Summary: This empirical study investigated the real-world glycaemic outcomes and goals achieved by users of the MiniMed 780G advanced hybrid closed loop system in different age groups of type 1 diabetes patients. The results show that both patients aged 15 years or younger and patients aged older than 15 years achieved good blood glucose control with the use of the AHCL system, in line with the international consensus recommendations.

DIABETES OBESITY & METABOLISM (2022)

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Review Endocrinology & Metabolism

Significance of the CGM metric of time in range in children and adolescents with type 1 diabetes

Tatsuhiko Urakami

Summary: Continuous glucose monitoring (CGM) is challenging to achieve optimal glycemic control in pediatric patients with type 1 diabetes due to their irregular lifestyles and significant glycemic variation. Reducing hypoglycemic risk and minimizing time outside the target glucose range to less than 5% are key goals for effective blood glucose management in pediatric patients.

ENDOCRINE JOURNAL (2022)

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Article Endocrinology & Metabolism

The Management of Type 1 Diabetes in Adults. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)

Richard I. G. Holt et al.

Summary: This article discusses a consensus statement on the management of type 1 diabetes in adults, covering various aspects such as diagnosis, treatment goals, self-management education and support, with the aim of helping healthcare professionals better manage patients with this condition.

DIABETES CARE (2021)

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Article Endocrinology & Metabolism

Hybrid closed-loop glucose control with faster insulin aspart compared with standard insulin aspart in adults with type 1 diabetes: A double-blind, multicentre, multinational, randomized, crossover study

Charlotte K. Boughton et al.

Summary: The study found that the use of Fiasp in the CamAPS FX closed-loop system may reduce hypoglycemia without compromising glucose control in adults with T1D.

DIABETES OBESITY & METABOLISM (2021)

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Review Endocrinology & Metabolism

New closed-loop insulin systems

Charlotte K. Boughton et al.

Summary: Advances in diabetes technologies have led to the development of automated closed-loop insulin delivery systems, which are changing the way type 1 diabetes is managed. This review examines the evidence supporting currently available closed-loop systems and those in development, including DIY systems, as well as the challenges and potential enhancements for clinical adoption.

DIABETOLOGIA (2021)

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Article Endocrinology & Metabolism

One Year Real-World Use of the Control-IQ Advanced Hybrid Closed-Loop Technology

Marc D. Breton et al.

Summary: In a real-world analysis of Control-IQ technology users, the study found that the technology demonstrated good glycemic improvements in different types of diabetes patients. Over the 12-month observation period, the level of time spent in automation remained high, and the time within the blood glucose control target range also increased.

DIABETES TECHNOLOGY & THERAPEUTICS (2021)

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Review Pediatrics

Benefits and Challenges of Current Closed-Loop Technologies in Children and Young People With Type 1 Diabetes

Julia Fuchs et al.

Summary: Recent advances in diabetes technology have led to the development of closed-loop insulin delivery systems for the management of type 1 diabetes. While all available systems have shown improvements in glycemic control and quality of life, challenges in using closed-loop systems vary among different pediatric age-groups. Understanding the capabilities and differences of current systems can be challenging for healthcare professionals, caregivers, and young people with type 1 diabetes.

FRONTIERS IN PEDIATRICS (2021)

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Review Endocrinology & Metabolism

Severe Hypoglycemia: Is It Still a Threat for Children and Adolescents With Type 1 Diabetes?

Tatsuhiko Urakami

FRONTIERS IN ENDOCRINOLOGY (2020)

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Article Endocrinology & Metabolism

Clinical Targets for Continuous Glucose Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range

Tadej Battelino et al.

DIABETES CARE (2019)

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Real-World Evidence Analysis of a Hybrid Closed-Loop System

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